Atlas One · Host Biology · Scale 03 — Molecular

IL-4

IL-4 (Th2 cytokine) drives B cell IgE class switching, Th2 differentiation via STAT6/GATA-3, and epithelial barrier suppression; dupilumab (anti-IL-4Rα) blocks IL-4 and IL-13 signaling and is FDA-approved for atopic dermatitis, asthma, and CRSwNP.

Also known as: IL-4, interleukin-4, IL4, Th2 cytokine, STAT6, dupilumab, IL-4Rα, IL-13Rα1, type 2 immunity

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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il-4

IL-4

IL-4 (Th2 cytokine) drives B cell IgE class switching, Th2 differentiation via STAT6/GATA-3, and epithelial barrier suppression; dupilumab (anti-IL-4Rα) blocks IL-4 and IL-13 signaling and is FDA-approved for atopic dermatitis, asthma, and CRSwNP.

Entry Metadata

FieldValue
IDil-4
NameIL-4
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAtopic Dermatitis connects-toAsthma connects-toIge connects-toJak1 2

Sources