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ige
IgE
IgE is the lowest-abundance but highest-affinity immunoglobulin; allergen-specific IgE binds FcεRI on mast cells → cross-linking by allergen → degranulation → histamine, leukotrienes, and PGD2; omalizumab (anti-IgE) reduces severe allergic asthma exacerbations and anaphylaxis.
Entry Metadata
| Field | Value |
|---|---|
| ID | ige |
| Name | IgE |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol. 2008;8(3):205-217. · PubMed 18301424
- Busse W, Corren J, Lanier BQ, et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol. 2001;108(2):184-190. · PubMed 11496232