Atlas One · Host Biology · Scale 07 — System

Essential Thrombocythemia

Essential thrombocythemia is a JAK2/CALR/MPL-driven MPN with megakaryocytic hyperplasia and thrombocytosis; JAK2 V617F ~55-60%; CALR ~20-25%; MPL ~5-8%; risk-stratified aspirin ± hydroxyurea; anagrelide second-line; post-ET MF (~1-2%) and AML (<1%) transformation risk.

Also known as: essential thrombocythemia, ET, essential thrombocytosis, primary thrombocythemia, JAK2 thrombocythemia, CALR ET

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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essential-thrombocythemia

Essential Thrombocythemia

Essential thrombocythemia is a JAK2/CALR/MPL-driven MPN with megakaryocytic hyperplasia and thrombocytosis; JAK2 V617F ~55-60%; CALR ~20-25%; MPL ~5-8%; risk-stratified aspirin ± hydroxyurea; anagrelide second-line; post-ET MF (~1-2%) and AML (<1%) transformation risk.

Entry Metadata

FieldValue
IDessential-thrombocythemia
NameEssential Thrombocythemia
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMpl connects-toJak2 connects-toCalr connects-toTgf Beta connects-toVon Willebrand Factor connects-toPolycythemia Vera connects-toPlatelet connects-toDisseminated Intravascular Coagulation connects-toBone Marrow connects-toSpleen connects-toMyeloproliferative Neoplasms connects-toMyelofibrosis connects-toVenous Thromboembolism

Sources