Atlas One · Host Biology · Scale 07 — System

Essential Thrombocythemia

Essential thrombocythemia is a JAK2/CALR/MPL-driven MPN with megakaryocytic hyperplasia and thrombocytosis; JAK2 V617F ~55-60%; CALR ~20-25%; MPL ~5-8%; risk-stratified aspirin ± hydroxyurea; anagrelide second-line; post-ET MF (~1-2%) and AML (<1%) transformation risk.

Also known as: essential thrombocythemia, ET, essential thrombocytosis, primary thrombocythemia, JAK2 thrombocythemia, CALR ET

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
essential-thrombocythemia

Essential Thrombocythemia

Essential thrombocythemia is a JAK2/CALR/MPL-driven MPN with megakaryocytic hyperplasia and thrombocytosis; JAK2 V617F ~55-60%; CALR ~20-25%; MPL ~5-8%; risk-stratified aspirin ± hydroxyurea; anagrelide second-line; post-ET MF (~1-2%) and AML (<1%) transformation risk.

Entry Metadata

FieldValue
IDessential-thrombocythemia
NameEssential Thrombocythemia
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMpl connects-toJak2 connects-toCalr connects-toTgf Beta connects-toVon Willebrand Factor connects-toPolycythemia Vera connects-toPlatelet connects-toDisseminated Intravascular Coagulation connects-toBone Marrow connects-toSpleen connects-toMyeloproliferative Neoplasms connects-toMyelofibrosis connects-toVenous Thromboembolism connects-toCml connects-toStroke connects-toErythrocyte connects-toThrombin connects-toAml connects-toNeutrophil connects-toEndothelial Cell connects-toLiver connects-toNervous System connects-toPlacenta connects-toSkin connects-toGout connects-toThrombopoietin connects-toStat3 connects-toCalcium connects-toPotassium connects-toBrain connects-toIl 6 connects-toOxygen connects-toHeart connects-toFibrinogen connects-toPhoton connects-toLarge Intestine connects-toFibrosis connects-toElectron connects-toEye connects-toKidney connects-toNeuron connects-toReproductive System connects-toStomach connects-toAtherosclerosis connects-toTet2 connects-toIron connects-toNf Kb connects-toMacrophage connects-toPulmonary Arterial Hypertension connects-toDnmt3A connects-toMds connects-toHeart Failure connects-toHcc connects-toInherited Thrombophilia connects-toPnh connects-toAnemia Of Chronic Disease connects-toSepsis connects-toMajor Depressive Disorder connects-toNeuropathic Pain connects-toWound Healing connects-toBasal Cell Carcinoma connects-toIntegumentary System connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toLymphatic System connects-toRespiratory System connects-toRenal System connects-toCardiovascular System connects-toAspirin connects-toMusculoskeletal System connects-toCancer Chemotherapy connects-toAntiphospholipid Syndrome connects-toTargeted Therapy connects-toArterial Wall connects-toHepatic Lobule connects-toHeparin Induced Thrombocytopenia connects-toMyocardium connects-toGlomerulus connects-toCmml connects-toHemophilia A connects-toPeripheral Nerve connects-toCovid 19 Disease connects-toType I Interferon connects-toEzh2 connects-toAkt connects-toTnf Alpha connects-toNlrp3 Inflammasome connects-toVegf connects-toPf4 connects-toS100A8 A9 connects-toRunx1 connects-toProstaglandins connects-toPdgf connects-toXanthine Oxidase connects-toSf3B1 connects-toBcl 2 connects-toComplement C3 connects-toErk1 2 connects-toPik3Ca connects-toP53 connects-toMtor connects-toIl 1B connects-toMyd88 connects-toStat1 connects-toGalectin 3 connects-toPten connects-toCgas Sting connects-toSmad4 connects-toFoxo connects-toJak1 2 connects-toGsk 3B connects-toHif 1Alpha connects-toMdm2 connects-toPerforin connects-toCdk4 6 connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toCalcineurin connects-toNitric Oxide connects-toTroponin Complex connects-toSerotonin connects-toAdamts13 connects-toProtein C connects-toIl 10 connects-toEndothelin 1 connects-toAngiopoietin connects-toLung connects-toIl 4 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toAml connects-toIron connects-toIl 13 connects-toNatural Killer Cell connects-toHepatocyte connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toT Helper Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin

Sources