Atlas One · Host Biology · Scale 07 — System

Basal Cell Carcinoma

Most common human malignancy (~4 million/year in US); arises from basal keratinocytes driven by UV damage and PTCH1 loss. SMO mutations in ~40% of sporadic BCC activate Hedgehog-GLI → cyclin D1 and MYC; vismodegib and sonidegib are approved SMO inhibitors for advanced BCC.

Also known as: BCC, basal cell carcinoma, basal cell nevus syndrome, Gorlin syndrome, rodent ulcer, basal cell cancer, BCNevus

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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basal-cell-carcinoma

Basal Cell Carcinoma

Most common human malignancy (~4 million/year in US); arises from basal keratinocytes driven by UV damage and PTCH1 loss. SMO mutations in ~40% of sporadic BCC activate Hedgehog-GLI → cyclin D1 and MYC; vismodegib and sonidegib are approved SMO inhibitors for advanced BCC.

Entry Metadata

FieldValue
IDbasal-cell-carcinoma
NameBasal Cell Carcinoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPd 1 connects-toP53 connects-toRb1 connects-toWnt Beta Catenin connects-toPtch1 connects-toSmo connects-toSkin connects-toGorlin Syndrome connects-toMelanoma connects-toT Cytotoxic Cell connects-toPhoton connects-toImmune System connects-toFibroblast

Sources