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basal-cell-carcinoma
Basal Cell Carcinoma
Most common human malignancy (~4 million/year in US); arises from basal keratinocytes driven by UV damage and PTCH1 loss. SMO mutations in ~40% of sporadic BCC activate Hedgehog-GLI → cyclin D1 and MYC; vismodegib and sonidegib are approved SMO inhibitors for advanced BCC.
Entry Metadata
| Field | Value |
|---|---|
| ID | basal-cell-carcinoma |
| Name | Basal Cell Carcinoma |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toPd 1
connects-toP53
connects-toRb1
connects-toWnt Beta Catenin
connects-toPtch1
connects-toSmo
connects-toSkin
connects-toGorlin Syndrome
connects-toMelanoma
connects-toT Cytotoxic Cell
connects-toPhoton
connects-toImmune System
connects-toFibroblast
connects-toRothmund Thomson
connects-toHiv Aids
connects-toMedulloblastoma
connects-toNatural Killer Cell
connects-toVegf
connects-toCollagen
connects-toIntegumentary System
connects-toCdkn2A
connects-toVitamin D
connects-toEye
connects-toDendritic Cell
connects-toMast Cell
connects-toTgf Beta
connects-toRegulatory T Cell
connects-toMacrophage
connects-toOxygen
connects-toNf Kb
connects-toHif 1Alpha
connects-toFibrosis
connects-toPeripheral Nerve
connects-toEndothelial Cell
connects-toBrain
connects-toCalcium
connects-toBcl 2
connects-toElectron
connects-toLung
connects-toBone Marrow
connects-toNeuron
connects-toMusculoskeletal System
connects-toAntibody
connects-toReproductive System
connects-toNeutrophil
connects-toThyroid
connects-toEgfr
connects-toCyclin D1
connects-toHpv 16
connects-toPsoriasis
connects-toGvhd
connects-toAdipocyte
connects-toStat3
connects-toCll
connects-toSepsis
connects-toHiv
connects-toWound Healing
connects-toMajor Depressive Disorder
connects-toBladder Cancer
connects-toCkd
connects-toGeneralized Anxiety Disorder
connects-toNervous System
connects-toNeuropathic Pain
connects-toDigestive System
connects-toLymphatic System
connects-toRespiratory System
connects-toCardiovascular System
connects-toRenal System
connects-toEndocrine System
connects-toSulforaphane
connects-toTargeted Therapy
connects-toCheckpoint Inhibitors
connects-toHnscc
connects-toCancer Chemotherapy
connects-toCortical Bone
connects-toLung Slice
connects-toRhabdomyosarcoma
connects-toNotch
connects-toTert
connects-toBloom Syndrome
connects-toWerner Syndrome
connects-toRheumatoid Arthritis
connects-toSufu
connects-toYap1
connects-toPten
connects-toMyc
connects-toEzh2
connects-toFgfr
connects-toAkt
connects-toMtor
connects-toCcl2
connects-toCgas Sting
connects-toCaspase 3
connects-toPdgf
connects-toCalcium
connects-toPerforin
connects-toIgf 1
connects-toPik3Ca
connects-toE2F1
connects-toNfe2L2
connects-toErk1 2
connects-toMyd88
connects-toIl 6
connects-toJak1 2
connects-toSmad4
connects-toGalectin 3
connects-toCdk4 6
connects-toStat1
connects-toFoxo
connects-toS100A8 A9
connects-toGsk 3B
connects-toMdm2
connects-toSrc Kinase
connects-toDnmt3A
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toArid1A
connects-toCxcl12
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toCalcineurin
connects-toMhc Class Ii
connects-toIl 2
connects-toCtla 4
connects-toIl 10
connects-toNitric Oxide
connects-toT Helper Cell
connects-toCholesterol
connects-toProstaglandins
connects-toXanthine Oxidase
connects-toIl 4
connects-toCopper
connects-toZinc
connects-toPhoton
connects-toIl 13
connects-toSelenium
connects-toMacrophage
connects-toMelanoma
connects-toDendritic Cell
connects-toIfn Gamma
connects-toIl 12
connects-toType I Interferon
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toB Cell
connects-toPlasma Cell
connects-toC5Ar1
connects-toComplement C5
connects-toFactor H
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toMelatonin
connects-toTestosterone
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toIodine
connects-toSodium
connects-toIron
connects-toMagnesium
connects-toPhosphorus
connects-toPotassium
connects-toChloride
connects-toSulfur
connects-toCarbon
connects-toHydrogen
connects-toNitrogen
connects-toGlp 1
connects-toAngiotensin Ii
connects-toRankl
connects-toFibronectin
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toAdrenomedullin
connects-toNorepinephrine
connects-toBdnf
connects-toOsteopontin
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
Sources
- Sekulic A, Migden MR, Oro AE, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med. 2012;366(23):2171-2179. · PubMed 22670902
- Stratigos AJ, Sekulic A, Peris K, et al. Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial (EMPOWER-BCC 1). Lancet Oncol. 2021;22(6):848-857. · PubMed 33930313