Atlas One · Host Biology · Scale 07 — System

Basal Cell Carcinoma

Most common human malignancy (~4 million/year in US); arises from basal keratinocytes driven by UV damage and PTCH1 loss. SMO mutations in ~40% of sporadic BCC activate Hedgehog-GLI → cyclin D1 and MYC; vismodegib and sonidegib are approved SMO inhibitors for advanced BCC.

Also known as: BCC, basal cell carcinoma, basal cell nevus syndrome, Gorlin syndrome, rodent ulcer, basal cell cancer, BCNevus

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
basal-cell-carcinoma

Basal Cell Carcinoma

Most common human malignancy (~4 million/year in US); arises from basal keratinocytes driven by UV damage and PTCH1 loss. SMO mutations in ~40% of sporadic BCC activate Hedgehog-GLI → cyclin D1 and MYC; vismodegib and sonidegib are approved SMO inhibitors for advanced BCC.

Entry Metadata

FieldValue
IDbasal-cell-carcinoma
NameBasal Cell Carcinoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPd 1 connects-toP53 connects-toRb1 connects-toWnt Beta Catenin connects-toPtch1 connects-toSmo connects-toSkin connects-toGorlin Syndrome connects-toMelanoma connects-toT Cytotoxic Cell connects-toPhoton connects-toImmune System connects-toFibroblast connects-toRothmund Thomson connects-toHiv Aids connects-toMedulloblastoma connects-toNatural Killer Cell connects-toVegf connects-toCollagen connects-toIntegumentary System connects-toCdkn2A connects-toVitamin D connects-toEye connects-toDendritic Cell connects-toMast Cell connects-toTgf Beta connects-toRegulatory T Cell connects-toMacrophage connects-toOxygen connects-toNf Kb connects-toHif 1Alpha connects-toFibrosis connects-toPeripheral Nerve connects-toEndothelial Cell connects-toBrain connects-toCalcium connects-toBcl 2 connects-toElectron connects-toLung connects-toBone Marrow connects-toNeuron connects-toMusculoskeletal System connects-toAntibody connects-toReproductive System connects-toNeutrophil connects-toThyroid connects-toEgfr connects-toCyclin D1 connects-toHpv 16 connects-toPsoriasis connects-toGvhd connects-toAdipocyte connects-toStat3 connects-toCll connects-toSepsis connects-toHiv connects-toWound Healing connects-toMajor Depressive Disorder connects-toBladder Cancer connects-toCkd connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toNeuropathic Pain connects-toDigestive System connects-toLymphatic System connects-toRespiratory System connects-toCardiovascular System connects-toRenal System connects-toEndocrine System connects-toSulforaphane connects-toTargeted Therapy connects-toCheckpoint Inhibitors connects-toHnscc connects-toCancer Chemotherapy connects-toCortical Bone connects-toLung Slice connects-toRhabdomyosarcoma connects-toNotch connects-toTert connects-toBloom Syndrome connects-toWerner Syndrome connects-toRheumatoid Arthritis connects-toSufu connects-toYap1 connects-toPten connects-toMyc connects-toEzh2 connects-toFgfr connects-toAkt connects-toMtor connects-toCcl2 connects-toCgas Sting connects-toCaspase 3 connects-toPdgf connects-toCalcium connects-toPerforin connects-toIgf 1 connects-toPik3Ca connects-toE2F1 connects-toNfe2L2 connects-toErk1 2 connects-toMyd88 connects-toIl 6 connects-toJak1 2 connects-toSmad4 connects-toGalectin 3 connects-toCdk4 6 connects-toStat1 connects-toFoxo connects-toS100A8 A9 connects-toGsk 3B connects-toMdm2 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toIl 2 connects-toCtla 4 connects-toIl 10 connects-toNitric Oxide connects-toT Helper Cell connects-toCholesterol connects-toProstaglandins connects-toXanthine Oxidase connects-toIl 4 connects-toCopper connects-toZinc connects-toPhoton connects-toIl 13 connects-toSelenium connects-toMacrophage connects-toMelanoma connects-toDendritic Cell connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toB Cell connects-toPlasma Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toIron connects-toMagnesium connects-toPhosphorus connects-toPotassium connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toNorepinephrine connects-toBdnf connects-toOsteopontin connects-toEpinephrine connects-toRenin connects-toMyostatin