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bloom-syndrome
Bloom Syndrome
Bloom syndrome is caused by biallelic BLM mutations; small body size, sun-sensitive telangiectatic facial erythema, immunodeficiency; elevated sister chromatid exchanges (~10x); pan-cancer predisposition (ALL, lymphoma, GI carcinoma, skin cancers); median survival ~30 years.
Entry Metadata
| Field | Value |
|---|---|
| ID | bloom-syndrome |
| Name | Bloom Syndrome |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toBlm
connects-toBrca1
connects-toWrn
connects-toColorectal Cancer
connects-toBurkitt Lymphoma
connects-toApc
connects-toMlh1
connects-toDicer1 Syndrome
connects-toSkin
connects-toAll
connects-toWerner Syndrome
connects-toAml
connects-toPhoton
connects-toRothmund Thomson
connects-toType 2 Diabetes
connects-toImmune System
connects-toLi Fraumeni Syndrome
connects-toP53
connects-toRad51
connects-toBrca2
connects-toB Cell
connects-toReproductive System
connects-toGrowth Hormone
connects-toLung
connects-toBreast Cancer
connects-toAtm
connects-toImmunoglobulin G
connects-toT Helper Cell
connects-toOxygen
connects-toLarge Intestine
connects-toFibroblast
connects-toBone Marrow
connects-toPancreas
connects-toNatural Killer Cell
connects-toEndothelial Cell
connects-toIntestinal Epithelium
connects-toLiver
connects-toElectron
connects-toEye
connects-toKidney
connects-toAntibody
connects-toErythrocyte
connects-toStomach
connects-toThymus
connects-toInsulin
connects-toT Cytotoxic Cell
connects-toIgf 1
connects-toMds
connects-toPlasma Cell
connects-toEsophageal Cancer
connects-toWilms Tumor
connects-toMsh2
connects-toNf Kb
connects-toSepsis
connects-toCervical Cancer
connects-toCopd
connects-toAnemia Of Chronic Disease
connects-toMajor Depressive Disorder
connects-toStreptococcus Pneumoniae
connects-toAspergillus Fumigatus
connects-toWound Healing
connects-toIntegumentary System
connects-toEndocrine System
connects-toGeneralized Anxiety Disorder
connects-toMusculoskeletal System
connects-toRespiratory System
connects-toDigestive System
connects-toLymphatic System
connects-toRenal System
connects-toCardiovascular System
connects-toCancer Chemotherapy
connects-toBasal Cell Carcinoma
connects-toGastric Cancer
connects-toTargeted Therapy
connects-toCheckpoint Inhibitors
connects-toGerminal Center
connects-toAplastic Anemia
connects-toCortical Bone
connects-toPancreatic Cancer
connects-toDlbcl
connects-toOsteosarcoma
connects-toHepatic Lobule
connects-toLynch Syndrome
connects-toAtrx
connects-toMelanoma
connects-toMyc
connects-toTert
connects-toCyclin D1
connects-toRecql4
connects-toPalb2
connects-toCdkn2A
connects-toCdkn1A
connects-toCaspase 3
connects-toMdm2
connects-toCgas Sting
connects-toXanthine Oxidase
connects-toSecretory Iga
connects-toE2F1
connects-toCdk4 6
connects-toRb1
connects-toNfe2L2
connects-toAkt
connects-toVegf
connects-toMtor
connects-toPten
connects-toErk1 2
connects-toStat1
connects-toFoxo
connects-toGalectin 3
connects-toStat3
connects-toPerforin
connects-toGsk 3B
connects-toPik3Ca
connects-toS100A8 A9
connects-toHif 1Alpha
connects-toAmpk
connects-toAutophagy
connects-toDnmt3A
connects-toCcr5
connects-toCxcl12
connects-toArid1A
connects-toBcl 2
connects-toRunx1
connects-toIl 6
connects-toMhc Class Ii
connects-toInsulin Receptor
connects-toIl 2
connects-toType I Interferon
connects-toTnf Alpha
connects-toComplement C3
connects-toIl 1B
connects-toIl 10
connects-toSpleen
connects-toIl 4
connects-toIron
connects-toLeptin
connects-toIl 13
connects-toAdiponectin
connects-toResistin
connects-toColorectal Cancer
connects-toFibroblast
connects-toAll
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 17A
connects-toIl 23
connects-toIge
connects-toDendritic Cell
connects-toMacrophage
connects-toC5Ar1
connects-toComplement C5
connects-toFactor H
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toMelatonin
connects-toC1 Esterase Inhibitor
connects-toTestosterone
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toSodium
connects-toCalcium
connects-toMagnesium
connects-toIodine
connects-toCopper
connects-toZinc
connects-toCarbon
connects-toChloride
connects-toHydrogen
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toFibronectin
connects-toNotch
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf