Atlas One · Host Biology · Scale 03 — Molecular

WRN

WRN is a RecQ family 3'→5' helicase/exonuclease that resolves G-quadruplex DNA and stalled replication forks; WRN maintains telomere stability; biallelic WRN LOF = Werner syndrome — premature aging with early cataracts, sarcomas, diabetes, and accelerated atherosclerosis.

Also known as: WRN, Werner syndrome helicase, WRN helicase, WRN RecQ helicase, WRN exonuclease, RECQL2, Werner syndrome gene, WRN DNA repair, WRN telomere

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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wrn

WRN

WRN is a RecQ family 3'→5' helicase/exonuclease that resolves G-quadruplex DNA and stalled replication forks; WRN maintains telomere stability; biallelic WRN LOF = Werner syndrome — premature aging with early cataracts, sarcomas, diabetes, and accelerated atherosclerosis.

Entry Metadata

FieldValue
IDwrn
NameWRN
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toWerner Syndrome connects-toTert connects-toP53 connects-toBrca2

Sources