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tert
TERT
Catalytic subunit of telomerase; adds TTAGGG repeats to telomeres, preventing replicative senescence. Silenced in somatic cells; reactivated in ~90% of cancers via TERT promoter mutations (C228T/C250T) or MYC amplification — oncogenic drivers in GBM, melanoma, and bladder cancer.
Entry Metadata
| Field | Value |
|---|---|
| ID | tert |
| Name | TERT |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Shay JW, Wright WE. Hallmarks of telomeres in ageing research. J Pathol. 2007;211(2):114-123. · PubMed 17200946
- Huang FW, Hodis E, Xu MJ, Kryukov GV, Chin L, Garraway LA. Highly recurrent TERT promoter mutations in human melanoma. Science. 2013;339(6122):957-959. · PubMed 23348506
- Barthel FP, Wei W, Tang M, et al. Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet. 2017;49(3):349-357. · PubMed 28135248