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werner-syndrome
Werner Syndrome
Werner syndrome is caused by biallelic WRN mutations; premature aging onset in 3rd decade — cataracts, scleroderma-like skin, gray hair, type 2 diabetes, dyslipidemia, osteoporosis, atherosclerosis; cancer risk elevated (sarcomas, melanoma, thyroid); median survival ~47-54 years.
Entry Metadata
| Field | Value |
|---|---|
| ID | werner-syndrome |
| Name | Werner Syndrome |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toWrn
connects-toTert
connects-toType 2 Diabetes
connects-toOsteoporosis
connects-toFibroblast
connects-toEye
connects-toAtherosclerosis
connects-toBloom Syndrome
connects-toOsteosarcoma
connects-toThyroid Cancer
connects-toRothmund Thomson
connects-toMelanoma
connects-toMeningioma
connects-toLi Fraumeni Syndrome
connects-toCdkn2A
connects-toCardiovascular System
connects-toP53
connects-toSkin
connects-toFibrosis
connects-toColorectal Cancer
connects-toAdipocyte
connects-toMusculoskeletal System
connects-toAtm
connects-toInsulin
connects-toMtor
connects-toRad51
connects-toOxygen
connects-toCollagen
connects-toHeart
connects-toCalcium
connects-toOsteoblast
connects-toEndothelial Cell
connects-toPancreas
connects-toBone Marrow
connects-toPhoton
connects-toLarge Intestine
connects-toLiver
connects-toGrowth Hormone
connects-toTestosterone
connects-toElectron
connects-toAntibody
connects-toErythrocyte
connects-toNeutrophil
connects-toReproductive System
connects-toSmooth Muscle Cell
connects-toThyroid
connects-toRecql4
connects-toWound Healing
connects-toMacrophage
connects-toNf Kb
connects-toStat3
connects-toVenous Thromboembolism
connects-toStroke
connects-toHeart Failure
connects-toMds
connects-toAml
connects-toStaphylococcus Aureus
connects-toMajor Depressive Disorder
connects-toIntegumentary System
connects-toEndocrine System
connects-toGeneralized Anxiety Disorder
connects-toDigestive System
connects-toImmune System
connects-toNervous System
connects-toRenal System
connects-toLymphatic System
connects-toStaphylococcus Aureus
connects-toMetformin
connects-toStatins
connects-toAspirin
connects-toCancer Chemotherapy
connects-toCortical Bone
connects-toArterial Wall
connects-toTargeted Therapy
connects-toLynch Syndrome
connects-toIslet Of Langerhans
connects-toEndometrial Cancer
connects-toMyocardium
connects-toSynovial Sarcoma
connects-toBrca1
connects-toNash
connects-toFamilial Hypercholesterolemia
connects-toCyclin D1
connects-toMyc
connects-toAkt
connects-toVegf
connects-toPdgf
connects-toHif 1Alpha
connects-toBlm
connects-toCdkn1A
connects-toRankl
connects-toCgas Sting
connects-toCholesterol
connects-toAdiponectin
connects-toIl 6
connects-toE2F1
connects-toAmpk
connects-toNfe2L2
connects-toTnf Alpha
connects-toAtrx
connects-toJak1 2
connects-toNlrp3 Inflammasome
connects-toMdm2
connects-toStat1
connects-toGalectin 3
connects-toSmad4
connects-toFoxo
connects-toPerforin
connects-toS100A8 A9
connects-toGsk 3B
connects-toCdk4 6
connects-toSrc Kinase
connects-toPik3Ca
connects-toDnmt3A
connects-toAutophagy
connects-toCcr5
connects-toArid1A
connects-toIl 1B
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toNitric Oxide
connects-toSclerostin
connects-toResistin
connects-toTroponin Complex
connects-toMhc Class Ii
connects-toXanthine Oxidase
connects-toIl 10
connects-toGlp 1
connects-toProstaglandins
connects-toLeptin
connects-toPcsk9
connects-toIgf 1
connects-toIl 4
connects-toIl 13
connects-toIron
connects-toType I Interferon
connects-toBloom Syndrome
connects-toOsteosarcoma
connects-toNatural Killer Cell
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toT Helper Cell
connects-toDendritic Cell
connects-toComplement C3
connects-toC5Ar1
connects-toT Cytotoxic Cell
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toPeriostin
connects-toMelatonin
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toMagnesium
connects-toCopper
connects-toZinc
connects-toPotassium
connects-toCarbon
connects-toChloride
connects-toHydrogen
connects-toNitrogen
connects-toSulfur
connects-toPhosphorus
connects-toPd 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin