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meningioma
Meningioma
Meningioma is the most common intracranial tumor; WHO grades 1-3; NF2 LOF ~50-60%, AKT1 E17K ~10-12%, TRAF7 ~25%; grade 1 5-year recurrence: GTR ~7%; grade 2 ~40%; grade 3 ~80%; surgery ± SRS for grade 1-2; RT for grade 3; bevacizumab and mTOR inhibitors for recurrent disease.
Entry Metadata
| Field | Value |
|---|---|
| ID | meningioma |
| Name | Meningioma |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Brastianos PK, Horowitz PM, Santagata S, et al. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013;45(3):285-289. · PubMed 23334667
- Nassiri F, Liu J, Patil V, et al. A clinically applicable integrative molecular classification of meningiomas. Nature. 2021;597(7874):119-125. · PubMed 34385709