Atlas One · Host Biology · Scale 07 — System

Neurofibromatosis Type 2

Neurofibromatosis type 2 (NF2) is caused by germline NF2 mutations; bilateral vestibular schwannomas are pathognomonic; meningiomas, ependymomas also occur; merlin activates Hippo-YAP1; bevacizumab improves hearing; TEAD inhibitors in clinical trials.

Also known as: NF2, neurofibromatosis type 2, NF2 syndrome, bilateral acoustic neuroma, NF2 vestibular schwannoma, NF2 merlin, NF2 bevacizumab, neurofibromatosis 2, acoustic neuroma hereditary

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
neurofibromatosis-type-2

Neurofibromatosis Type 2

Neurofibromatosis type 2 (NF2) is caused by germline NF2 mutations; bilateral vestibular schwannomas are pathognomonic; meningiomas, ependymomas also occur; merlin activates Hippo-YAP1; bevacizumab improves hearing; TEAD inhibitors in clinical trials.

Entry Metadata

FieldValue
IDneurofibromatosis-type-2
NameNeurofibromatosis Type 2
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toNf2 connects-toYap1 connects-toMeningioma connects-toMesothelioma connects-toVegf connects-toSchwannomatosis connects-toPeripheral Nerve connects-toNeurofibromatosis Type 1 connects-toBrain connects-toRenal Cell Carcinoma connects-toTuberous Sclerosis Complex connects-toUveal Melanoma connects-toAstrocyte connects-toGlioblastoma connects-toVhl Disease connects-toEye connects-toNeuron connects-toPhoton connects-toMtor connects-toNervous System connects-toSkin connects-toProton connects-toErk1 2 connects-toCyclin D1 connects-toEndothelial Cell connects-toCdkn2A connects-toMacrophage connects-toNatural Killer Cell connects-toAkt connects-toPdgf connects-toT Cytotoxic Cell connects-toPotassium connects-toSynapse connects-toFibroblast connects-toElectron connects-toCalcium connects-toTert connects-toOligodendrocyte connects-toCollagen connects-toLung connects-toAntibody connects-toIntegumentary System connects-toReproductive System connects-toPlatelet connects-toRegulatory T Cell connects-toStroke connects-toEgfr connects-toEpilepsy connects-toMast Cell connects-toSmarcb1 connects-toLztr1 connects-toNeuropathic Pain connects-toNf Kb connects-toStat3 connects-toSepsis connects-toMajor Depressive Disorder connects-toVenous Thromboembolism connects-toHypertension connects-toCkd connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toMusculoskeletal System connects-toCardiovascular System connects-toDigestive System connects-toRespiratory System connects-toImmune System connects-toEndocrine System connects-toTargeted Therapy connects-toGorlin Syndrome connects-toCarney Complex connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toCortical Bone connects-toHcc connects-toAtypical Teratoid Rhabdoid Tumor connects-toHepatic Lobule connects-toAxonal Transport connects-toFibrosis connects-toMyocardium connects-toMpnst connects-toNeuromuscular Junction connects-toLi Fraumeni Syndrome connects-toMet connects-toCdk4 6 connects-toNotch connects-toPik3Ca connects-toMyc connects-toHif 1Alpha connects-toCcl2 connects-toSrc Kinase connects-toSstr2 connects-toCxcl12 connects-toCaspase 3 connects-toKit connects-toCalcium connects-toDnmt3A connects-toIgf 1 connects-toE2F1 connects-toPten connects-toTgf Beta connects-toKras connects-toRb1 connects-toJak1 2 connects-toGalectin 3 connects-toSmad4 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toIl 6 connects-toEzh2 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toProgesterone connects-toBap1 connects-toAxl Receptor connects-toMhc Class Ii connects-toEstrogen connects-toIl 2 connects-toIl 10 connects-toNitric Oxide connects-toPd 1 connects-toIl 4 connects-toXanthine Oxidase connects-toProstaglandins connects-toIl 13 connects-toSkin connects-toT Cytotoxic Cell connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toDendritic Cell connects-toT Helper Cell connects-toPlasma Cell connects-toB Cell connects-toComplement C3 connects-toC5Ar1 connects-toTslp connects-toHistamine connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toCarbon connects-toChloride connects-toNitrogen connects-toHydrogen connects-toIron connects-toOxygen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine