Atlas One · Host Biology · Scale 07 — System

VHL Disease

Hereditary VHL disease is caused by germline VHL mutations; clear cell RCC, CNS and retinal hemangioblastomas, pheochromocytoma (type 2), and pancreatic NETs; belzutifan (HIF-2α inhibitor) is FDA-approved for VHL-related tumors; type 1/2A/2B/2C classification by pheo risk.

Also known as: VHL disease, von Hippel-Lindau disease, VHL syndrome, VHL hemangioblastoma, VHL RCC, hereditary VHL, VHL pheochromocytoma, VHL belzutifan, von Hippel-Lindau syndrome

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
vhl-disease

VHL Disease

Hereditary VHL disease is caused by germline VHL mutations; clear cell RCC, CNS and retinal hemangioblastomas, pheochromocytoma (type 2), and pancreatic NETs; belzutifan (HIF-2α inhibitor) is FDA-approved for VHL-related tumors; type 1/2A/2B/2C classification by pheo risk.

Entry Metadata

FieldValue
IDvhl-disease
NameVHL Disease
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toVhl connects-toEgln1 connects-toRenal Cell Carcinoma connects-toPheochromocytoma Paraganglioma connects-toHif 1Alpha connects-toBrain connects-toEye connects-toTuberous Sclerosis Complex connects-toPancreas connects-toErythropoietin connects-toHlrcc connects-toNeuroendocrine Tumors connects-toEndothelial Cell connects-toMen1 Syndrome connects-toBirt Hogg Dube Syndrome connects-toPolycythemia Vera connects-toKidney connects-toVegf connects-toOxygen connects-toAdrenal Gland connects-toReproductive System connects-toErythrocyte connects-toEpas1 connects-toSdhb connects-toIron connects-toMtor connects-toRegulatory T Cell connects-toNatural Killer Cell connects-toAkt connects-toDendritic Cell connects-toLiver connects-toBone Marrow connects-toNeuron connects-toPdgf connects-toPhoton connects-toLung connects-toAstrocyte connects-toHemoglobin connects-toElectron connects-toGlucagon connects-toAntibody connects-toHypertension connects-toNeutrophil connects-toCyclin D1 connects-toT Cytotoxic Cell connects-toStroke connects-toMet connects-toCkd connects-toMast Cell connects-toStat3 connects-toNf Kb connects-toVenous Thromboembolism connects-toEpilepsy connects-toMajor Depressive Disorder connects-toSepsis connects-toHeart Failure connects-toType 2 Diabetes connects-toNeuropathic Pain connects-toAnemia Of Chronic Disease connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toEndocrine System connects-toDigestive System connects-toCardiovascular System connects-toRespiratory System connects-toLymphatic System connects-toTargeted Therapy connects-toImmune System connects-toNeurofibromatosis Type 2 connects-toIslet Of Langerhans connects-toCancer Chemotherapy connects-toGist connects-toIdh Mutant Glioma connects-toArterial Wall connects-toMyeloproliferative Neoplasms connects-toDiabetic Retinopathy connects-toGlioblastoma connects-toNeurofibromatosis Type 1 connects-toPeripheral Nerve connects-toCortical Bone connects-toMen4 Syndrome connects-toMyc connects-toEzh2 connects-toYap1 connects-toCdk4 6 connects-toTert connects-toPik3Ca connects-toCxcl12 connects-toSstr2 connects-toAdrenomedullin connects-toFh connects-toAngiopoietin connects-toNorepinephrine connects-toEgfr connects-toBap1 connects-toNotch connects-toE2F1 connects-toPten connects-toErk1 2 connects-toIdh1 connects-toRb1 connects-toJak1 2 connects-toCgas Sting connects-toStat1 connects-toGalectin 3 connects-toFoxo connects-toSmad4 connects-toPerforin connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 6 connects-toIl 2 connects-toCalcium connects-toTransferrin connects-toMhc Class Ii connects-toPd 1 connects-toCtla 4 connects-toNitric Oxide connects-toIl 10 connects-toIron connects-toIl 4 connects-toCholesterol connects-toAdiponectin connects-toIl 13 connects-toLeptin connects-toResistin connects-toHepcidin connects-toType I Interferon connects-toMacrophage connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toT Helper Cell connects-toIl 23 connects-toIge connects-toB Cell connects-toComplement C5 connects-toC5Ar1 connects-toComplement C3 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTslp connects-toBradykinin connects-toPeriostin connects-toHistamine connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toVegf connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toBdnf connects-toOsteopontin