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bap1
BAP1
BAP1 (BRCA1-associated protein 1) is a nuclear deubiquitinase that removes H2AK119 ubiquitin → opposes PRC1 repression; germline BAP1 mutations cause BAP1 tumor predisposition syndrome (mesothelioma, uveal melanoma, ccRCC); somatic BAP1 loss in ~50-60% of mesothelioma.
Entry Metadata
| Field | Value |
|---|---|
| ID | bap1 |
| Name | BAP1 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Testa JR, Cheung M, Pei J, et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet. 2011;43(10):1022-1025. · PubMed 21874000
- Bott M, Brevet M, Taylor BS, et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and putative germline variants in sporadic malignant mesothelioma. Nat Genet. 2011;43(7):668-672. · PubMed 21642991