Atlas One · Host Biology · Scale 07 — System

Renal Cell Carcinoma

Clear cell RCC (~75%) is driven by VHL loss → HIF activation → VEGF angiogenesis; papillary type driven by MET and CDKN2A. Nivolumab+ipilimumab and pembrolizumab+axitinib are first-line for advanced RCC; cabozantinib is active after ICI progression.

Also known as: renal cell carcinoma, RCC, clear cell RCC, ccRCC, papillary RCC, chromophobe RCC, kidney cancer, renal carcinoma, VHL-mutant RCC

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
renal-cell-carcinoma

Renal Cell Carcinoma

Clear cell RCC (~75%) is driven by VHL loss → HIF activation → VEGF angiogenesis; papillary type driven by MET and CDKN2A. Nivolumab+ipilimumab and pembrolizumab+axitinib are first-line for advanced RCC; cabozantinib is active after ICI progression.

Entry Metadata

FieldValue
IDrenal-cell-carcinoma
NameRenal Cell Carcinoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toVegf connects-toPd 1 connects-toMtor connects-toHif 1Alpha connects-toKidney connects-toVhl Disease connects-toMet connects-toPheochromocytoma Paraganglioma connects-toHlrcc connects-toT Cytotoxic Cell connects-toTuberous Sclerosis Complex connects-toErythrocyte connects-toBladder Cancer connects-toBirt Hogg Dube Syndrome connects-toOvarian Clear Cell Carcinoma connects-toPolycythemia Vera connects-toVhl connects-toErythropoietin connects-toObesity connects-toBap1 connects-toRenal System connects-toImmune System connects-toEpas1 connects-toCalcium connects-toLung connects-toPth connects-toRegulatory T Cell connects-toMacrophage connects-toOxygen connects-toBrain connects-toDendritic Cell connects-toIron connects-toPancreas connects-toBone Marrow connects-toPhoton connects-toAdrenal Gland connects-toPlatelet connects-toElectron connects-toLiver connects-toSodium connects-toAntibody connects-toNeutrophil connects-toHypertension connects-toReproductive System connects-toSdhb connects-toCardiomyocyte connects-toPdgf connects-toCtla 4 connects-toCkd connects-toEndothelial Cell connects-toVenous Thromboembolism connects-toStroke connects-toIl 6 connects-toAnemia Of Chronic Disease connects-toSepsis connects-toHeart Failure connects-toType 1 Diabetes connects-toMajor Depressive Disorder connects-toWound Healing connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toEndocrine System connects-toMusculoskeletal System connects-toCardiovascular System connects-toNervous System connects-toLymphatic System connects-toTargeted Therapy connects-toCowden Syndrome connects-toTuberculosis connects-toCheckpoint Inhibitors connects-toCancer Chemotherapy connects-toCortical Bone connects-toMesothelioma connects-toEndocardium connects-toHcc connects-toAlveolus connects-toWilms Tumor connects-toHepatic Lobule connects-toInflammatory Bowel Disease connects-toArterial Wall connects-toMelanoma connects-toRenin connects-toAkt connects-toEzh2 connects-toMyc connects-toCyclin D1 connects-toPik3Ca connects-toAxl Receptor connects-toCxcl12 connects-toTert connects-toFh connects-toFlcn connects-toCdkn2A connects-toNfe2L2 connects-toCcl2 connects-toArid1A connects-toEgln1 connects-toErk1 2 connects-toPten connects-toJak1 2 connects-toRb1 connects-toIdh1 connects-toGalectin 3 connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toSmad4 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toMdm2 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toIl 2 connects-toRankl connects-toLeptin connects-toMhc Class Ii connects-toHemoglobin connects-toTroponin Complex connects-toIl 10 connects-toNitric Oxide connects-toXanthine Oxidase connects-toIl 4 connects-toCholesterol connects-toAdiponectin connects-toIl 13 connects-toBirt Hogg Dube Syndrome connects-toCortical Bone connects-toType I Interferon connects-toResistin connects-toHepcidin connects-toIfn Gamma connects-toIl 12 connects-toNatural Killer Cell connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toFibroblast connects-toComplement C3 connects-toTransferrin connects-toTslp connects-toHistamine connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toComplement C5 connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toSelenium connects-toIodine connects-toMagnesium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toZinc connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin

Sources