Atlas One · Host Biology · Scale 03 — Molecular

EGLN1

EGLN1 (PHD2) is the principal prolyl hydroxylase that marks HIF-1α/2α for VHL-mediated ubiquitination under normoxia; EGLN1 uses O₂ as cosubstrate — inactivated by hypoxia → HIF stabilized; PHD inhibitors (daprodustat, vadadustat) block EGLN1 to treat CKD anemia.

Also known as: EGLN1, PHD2, prolyl hydroxylase 2, HIF prolyl hydroxylase, HIFPH2, PHD inhibitor EGLN1, daprodustat target, oxygen sensor EGLN1, EGLN1 HIF VHL

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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egln1

EGLN1

EGLN1 (PHD2) is the principal prolyl hydroxylase that marks HIF-1α/2α for VHL-mediated ubiquitination under normoxia; EGLN1 uses O₂ as cosubstrate — inactivated by hypoxia → HIF stabilized; PHD inhibitors (daprodustat, vadadustat) block EGLN1 to treat CKD anemia.

Entry Metadata

FieldValue
IDegln1
NameEGLN1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHif 1Alpha connects-toVhl connects-toErythropoietin connects-toVhl Disease connects-toEpas1 connects-toCkd connects-toRenal Cell Carcinoma

Sources