Atlas One · Host Biology · Scale 03 — Molecular

VHL

VHL tumor suppressor targets HIF-1α for proteasomal degradation under normoxia; VHL loss → constitutive HIF activation → VEGF, PDGF, and EPO. Biallelic VHL inactivation causes clear cell RCC (~75%) and von Hippel-Lindau syndrome (hemangioblastomas, pheochromocytoma).

Also known as: VHL, von Hippel-Lindau, VHL tumor suppressor, HIF regulation, E3 ubiquitin ligase, clear cell RCC, von Hippel-Lindau disease, VBC complex

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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vhl

VHL

VHL tumor suppressor targets HIF-1α for proteasomal degradation under normoxia; VHL loss → constitutive HIF activation → VEGF, PDGF, and EPO. Biallelic VHL inactivation causes clear cell RCC (~75%) and von Hippel-Lindau syndrome (hemangioblastomas, pheochromocytoma).

Entry Metadata

FieldValue
IDvhl
NameVHL
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHif 1Alpha connects-toVegf connects-toMtor connects-toPik3Ca

Sources