Atlas One · Host Biology · Scale 03 — Molecular

EPAS1

EPAS1 encodes HIF-2α (bHLH-PAS TF) stabilized under hypoxia or VHL loss; PHD2 hydroxylation → VHL-mediated degradation; activates EPO/VEGF; belzutifan (HIF-2α inhibitor) FDA-approved for VHL disease-associated RCC; EPAS1 GOF mutations cause hereditary erythrocytosis.

Also known as: EPAS1, HIF-2alpha, HIF-2α, HIF2A, hypoxia-inducible factor 2, belzutifan target, VHL-HIF axis, EPAS1 erythrocytosis

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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epas1

EPAS1

EPAS1 encodes HIF-2α (bHLH-PAS TF) stabilized under hypoxia or VHL loss; PHD2 hydroxylation → VHL-mediated degradation; activates EPO/VEGF; belzutifan (HIF-2α inhibitor) FDA-approved for VHL disease-associated RCC; EPAS1 GOF mutations cause hereditary erythrocytosis.

Entry Metadata

FieldValue
IDepas1
NameEPAS1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toVhl connects-toJak2 connects-toMtor connects-toVegf connects-toEgln1 connects-toRenal Cell Carcinoma connects-toErythropoietin

Sources