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sdhb
SDHB
SDHB is the iron-sulfur subunit of mitochondrial complex II; LOF → succinate → PHD inhibition → HIF-1α pseudohypoxia + TET inhibition → CIMP; germline SDHB causes paraganglioma type 4 (malignancy risk ~30-40%); SDH-deficient GIST/RCC are WHO entities.
Entry Metadata
| Field | Value |
|---|---|
| ID | sdhb |
| Name | SDHB |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Astuti D, Latif F, Dallol A, et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet. 2001;69(1):49-54. · PubMed 11404820
- Selak MA, Armour SM, MacKenzie ED, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell. 2005;7(1):77-85. · PubMed 15652751