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tet2
TET2
TET2 encodes a 5-methylcytosine dioxygenase that converts 5mC → 5hmC → 5fC → 5caC → demethylation via TDG/BER; TET2 loss-of-function mutations occur in ~20% CHIP (most common), ~20% MDS, ~60% CMML, and ~60-80% AITL; IDH1/2-produced 2-HG inhibits TET2.
Entry Metadata
| Field | Value |
|---|---|
| ID | tet2 |
| Name | TET2 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Delhommeau F, Dupont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301. · PubMed 19474426
- Palomero T, Couronné L, Khiabanian H, et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet. 2014;46(2):166-170. · PubMed 24413734