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dnmt3a
DNMT3A
DNMT3A encodes de novo DNA methyltransferase 3A; R882H/C dominant-negative hotspot mutations in ~20% of AML and ~40% of CHIP cause focal hypomethylation → HSC clonal expansion; DNMT3A+NPM1+FLT3-ITD is the classic intermediate-risk AML triplet; no direct targeted therapy.
Entry Metadata
| Field | Value |
|---|---|
| ID | dnmt3a |
| Name | DNMT3A |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424-2433. · PubMed 21067377
- Jaiswal S, Fontanillas P, Flannick J, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371(26):2488-2498. · PubMed 25426837