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aml
AML
Clonal myeloid malignancy; key drivers: FLT3-ITD/TKD (~30%), NPM1 (~30%), DNMT3A (~20%), IDH1/2 (~20%), and KMT2A rearrangements. Venetoclax+azacitidine is frontline for unfit patients; midostaurin (FLT3) and enasidenib/ivosidenib (IDH2/1) are approved targeted therapies.
Entry Metadata
| Field | Value |
|---|---|
| ID | aml |
| Name | AML |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toFlt3
connects-toMyc
connects-toBcl 2
connects-toP53
connects-toCxcl12
connects-toBone Marrow
connects-toMds
connects-toIdh1
connects-toNeutrophil
connects-toCml
connects-toMyeloproliferative Neoplasms
connects-toAll
connects-toPhoton
connects-toNatural Killer Cell
connects-toMyelofibrosis
connects-toLi Fraumeni Syndrome
connects-toNoonan Syndrome
connects-toNpm1
connects-toErythrocyte
connects-toDisseminated Intravascular Coagulation
connects-toPlatelet
connects-toImmune System
connects-toSkin
connects-toT Cytotoxic Cell
connects-toIdh2
connects-toDnmt3A
connects-toTet2
connects-toAutophagy
connects-toRegulatory T Cell
connects-toOxygen
connects-toBrain
connects-toDendritic Cell
connects-toIron
connects-toSpleen
connects-toRunx1
connects-toElectron
connects-toPotassium
connects-toLiver
connects-toNeuron
connects-toLung
connects-toHeart
connects-toAntibody
connects-toKidney
connects-toReproductive System
connects-toCardiomyocyte
connects-toGvhd
connects-toKit
connects-toWnt Beta Catenin
connects-toSepsis
connects-toMacrophage
connects-toNf Kb
connects-toStat3
connects-toVenous Thromboembolism
connects-toAspergillus Fumigatus
connects-toCandida Albicans
connects-toHeart Failure
connects-toCkd
connects-toPneumocystis Jirovecii
connects-toMajor Depressive Disorder
connects-toVaricella Zoster Virus
connects-toAplastic Anemia
connects-toGeneralized Anxiety Disorder
connects-toIntegumentary System
connects-toNervous System
connects-toDigestive System
connects-toRespiratory System
connects-toRenal System
connects-toCardiovascular System
connects-toTargeted Therapy
connects-toMusculoskeletal System
connects-toEndocrine System
connects-toCancer Chemotherapy
connects-toCheckpoint Inhibitors
connects-toCll
connects-toCmml
connects-toMyocardium
connects-toPtcl
connects-toBreast Cancer
connects-toAlveolus
connects-toGlomerulus
connects-toIdh Mutant Glioma
connects-toStroke
connects-toGout
connects-toEzh2
connects-toAkt
connects-toHif 1Alpha
connects-toCdk4 6
connects-toVegf
connects-toTnf Alpha
connects-toMen1
connects-toSmo
connects-toMdm2
connects-toSrsf2
connects-toFoxo
connects-toPerforin
connects-toErk1 2
connects-toCaspase 3
connects-toPik3Ca
connects-toMtor
connects-toJak2
connects-toE2F1
connects-toKras
connects-toRb1
connects-toNfe2L2
connects-toGalectin 3
connects-toStat1
connects-toCgas Sting
connects-toSmad4
connects-toS100A8 A9
connects-toGsk 3B
connects-toSrc Kinase
connects-toJak1 2
connects-toCdkn2A
connects-toAmpk
connects-toArid1A
connects-toCcl2
connects-toCcr5
connects-toIl 6
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toMhc Class Ii
connects-toSf3B1
connects-toFibrinogen
connects-toHemoglobin
connects-toXanthine Oxidase
connects-toIl 2
connects-toTroponin Complex
connects-toProton
connects-toIl 10
connects-toMds
connects-toIl 4
connects-toAdiponectin
connects-toLeptin
connects-toCalcium
connects-toIl 13
connects-toResistin
connects-toHepcidin
connects-toAdipocyte
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toT Helper Cell
connects-toMast Cell
connects-toC5Ar1
connects-toComplement C5
connects-toFactor H
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toPeriostin
connects-toMelatonin
connects-toTestosterone
connects-toSerotonin
connects-toOxytocin
connects-toVasopressin
connects-toProlactin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toZinc
connects-toMagnesium
connects-toCopper
connects-toPhosphorus
connects-toNitrogen
connects-toCarbon
connects-toChloride
connects-toHydrogen
connects-toSulfur
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toRankl
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
Sources
- DiNardo CD, Jonas BA, Pullarkat V, et al. Azacitidine and venetoclax in previously untreated acute myeloid leukemia. N Engl J Med. 2020;383(7):617-629. · PubMed 32786187
- Stone RM, Mandrekar SJ, Sanford BL, et al. Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation. N Engl J Med. 2017;377(5):454-464. · PubMed 28644114
- Stein EM, DiNardo CD, Pollyea DA, et al. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia. Blood. 2017;130(6):722-731. · PubMed 28588020