Atlas One · Host Biology · Scale 07 — System

AML

Clonal myeloid malignancy; key drivers: FLT3-ITD/TKD (~30%), NPM1 (~30%), DNMT3A (~20%), IDH1/2 (~20%), and KMT2A rearrangements. Venetoclax+azacitidine is frontline for unfit patients; midostaurin (FLT3) and enasidenib/ivosidenib (IDH2/1) are approved targeted therapies.

Also known as: acute myeloid leukemia, AML, acute myelogenous leukemia, myeloid leukemia, APL, acute promyelocytic leukemia, FLT3-mutant AML, IDH-mutant AML, NPM1-mutant AML

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
aml

AML

Clonal myeloid malignancy; key drivers: FLT3-ITD/TKD (~30%), NPM1 (~30%), DNMT3A (~20%), IDH1/2 (~20%), and KMT2A rearrangements. Venetoclax+azacitidine is frontline for unfit patients; midostaurin (FLT3) and enasidenib/ivosidenib (IDH2/1) are approved targeted therapies.

Entry Metadata

FieldValue
IDaml
NameAML
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toFlt3 connects-toMyc connects-toBcl 2 connects-toP53 connects-toCxcl12 connects-toBone Marrow connects-toMds connects-toIdh1 connects-toNeutrophil connects-toCml connects-toMyeloproliferative Neoplasms connects-toAll connects-toPhoton connects-toNatural Killer Cell connects-toMyelofibrosis connects-toLi Fraumeni Syndrome connects-toNoonan Syndrome connects-toNpm1 connects-toErythrocyte connects-toDisseminated Intravascular Coagulation connects-toPlatelet connects-toImmune System connects-toSkin connects-toT Cytotoxic Cell connects-toIdh2 connects-toDnmt3A connects-toTet2 connects-toAutophagy connects-toRegulatory T Cell connects-toOxygen connects-toBrain connects-toDendritic Cell connects-toIron connects-toSpleen connects-toRunx1 connects-toElectron connects-toPotassium connects-toLiver connects-toNeuron connects-toLung connects-toHeart connects-toAntibody connects-toKidney connects-toReproductive System connects-toCardiomyocyte connects-toGvhd connects-toKit connects-toWnt Beta Catenin connects-toSepsis connects-toMacrophage connects-toNf Kb connects-toStat3 connects-toVenous Thromboembolism connects-toAspergillus Fumigatus connects-toCandida Albicans connects-toHeart Failure connects-toCkd connects-toPneumocystis Jirovecii connects-toMajor Depressive Disorder connects-toVaricella Zoster Virus connects-toAplastic Anemia connects-toGeneralized Anxiety Disorder connects-toIntegumentary System connects-toNervous System connects-toDigestive System connects-toRespiratory System connects-toRenal System connects-toCardiovascular System connects-toTargeted Therapy connects-toMusculoskeletal System connects-toEndocrine System connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toCll connects-toCmml connects-toMyocardium connects-toPtcl connects-toBreast Cancer connects-toAlveolus connects-toGlomerulus connects-toIdh Mutant Glioma connects-toStroke connects-toGout connects-toEzh2 connects-toAkt connects-toHif 1Alpha connects-toCdk4 6 connects-toVegf connects-toTnf Alpha connects-toMen1 connects-toSmo connects-toMdm2 connects-toSrsf2 connects-toFoxo connects-toPerforin connects-toErk1 2 connects-toCaspase 3 connects-toPik3Ca connects-toMtor connects-toJak2 connects-toE2F1 connects-toKras connects-toRb1 connects-toNfe2L2 connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toSmad4 connects-toS100A8 A9 connects-toGsk 3B connects-toSrc Kinase connects-toJak1 2 connects-toCdkn2A connects-toAmpk connects-toArid1A connects-toCcl2 connects-toCcr5 connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toMhc Class Ii connects-toSf3B1 connects-toFibrinogen connects-toHemoglobin connects-toXanthine Oxidase connects-toIl 2 connects-toTroponin Complex connects-toProton connects-toIl 10 connects-toMds connects-toIl 4 connects-toAdiponectin connects-toLeptin connects-toCalcium connects-toIl 13 connects-toResistin connects-toHepcidin connects-toAdipocyte connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toMast Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toSelenium connects-toIodine connects-toSodium connects-toZinc connects-toMagnesium connects-toCopper connects-toPhosphorus connects-toNitrogen connects-toCarbon connects-toChloride connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin