Atlas One · Host Biology · Scale 03 — Molecular

NPM1

NPM1 (nucleophosmin) exon 12 insertions create cytoplasmic NPM1c in ~30% AML; NPM1c sequesters ARF → reduced p53 activity; NPM1c AML is a WHO-defined entity with favorable prognosis if FLT3-ITD negative; NPM1 mRNA is a sensitive MRD marker by RT-qPCR.

Also known as: NPM1, nucleophosmin, NPM1c, NPM1 AML, NPM1 mutation, NPM1c cytoplasmic, B23 nucleophosmin, NPM1-ALK

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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npm1

NPM1

NPM1 (nucleophosmin) exon 12 insertions create cytoplasmic NPM1c in ~30% AML; NPM1c sequesters ARF → reduced p53 activity; NPM1c AML is a WHO-defined entity with favorable prognosis if FLT3-ITD negative; NPM1 mRNA is a sensitive MRD marker by RT-qPCR.

Entry Metadata

FieldValue
IDnpm1
NameNPM1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toFlt3 connects-toP53 connects-toAlk connects-toTet2 connects-toDnmt3A connects-toIdh1 connects-toBcl 2

Sources