Atlas One · Host Biology · Scale 03 — Molecular

IDH1

Metabolic enzyme; IDH1 R132H and IDH2 R172K neomorphic mutations produce D-2-hydroxyglutarate → TET2 and KDM inhibition → DNA hypermethylation (G-CIMP) and HIF stabilization. IDH mutations define grade 2-3 gliomas; ivosidenib (IDH1) and vorasidenib are approved inhibitors.

Also known as: IDH1, IDH2, isocitrate dehydrogenase, IDH R132H, D-2-HG, 2-hydroxyglutarate, IDH-mutant, oncometabolite IDH

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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idh1

IDH1

Metabolic enzyme; IDH1 R132H and IDH2 R172K neomorphic mutations produce D-2-hydroxyglutarate → TET2 and KDM inhibition → DNA hypermethylation (G-CIMP) and HIF stabilization. IDH mutations define grade 2-3 gliomas; ivosidenib (IDH1) and vorasidenib are approved inhibitors.

Entry Metadata

FieldValue
IDidh1
NameIDH1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHif 1Alpha connects-toP53 connects-toMtor connects-toVegf

Sources