Atlas One · Host Biology · Scale 07 — System

Noonan Syndrome

Noonan syndrome is caused by germline RAS-MAPK pathway mutations (PTPN11 ~50%, SOS1, RAF1, KRAS, LZTR1, others); short stature, pulmonary stenosis, hypertrophic cardiomyopathy, and facial dysmorphia; elevated JMML/leukemia risk; MEK inhibitors in clinical trials.

Also known as: Noonan syndrome, Noonan's syndrome, PTPN11 Noonan, NS Noonan, RASopathy Noonan, Noonan syndrome heart, Noonan syndrome leukemia, Noonan syndrome cardiomyopathy, Noonan with lentigines, LEOPARD syndrome

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
noonan-syndrome

Noonan Syndrome

Noonan syndrome is caused by germline RAS-MAPK pathway mutations (PTPN11 ~50%, SOS1, RAF1, KRAS, LZTR1, others); short stature, pulmonary stenosis, hypertrophic cardiomyopathy, and facial dysmorphia; elevated JMML/leukemia risk; MEK inhibitors in clinical trials.

Entry Metadata

FieldValue
IDnoonan-syndrome
NameNoonan Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPtpn11 connects-toLztr1 connects-toKras connects-toNf1 connects-toHeart connects-toErk1 2 connects-toSchwannomatosis connects-toMarfan Syndrome connects-toNeurofibromatosis Type 1 connects-toLymphatic System

Sources