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noonan-syndrome
Noonan Syndrome
Noonan syndrome is caused by germline RAS-MAPK pathway mutations (PTPN11 ~50%, SOS1, RAF1, KRAS, LZTR1, others); short stature, pulmonary stenosis, hypertrophic cardiomyopathy, and facial dysmorphia; elevated JMML/leukemia risk; MEK inhibitors in clinical trials.
Entry Metadata
| Field | Value |
|---|---|
| ID | noonan-syndrome |
| Name | Noonan Syndrome |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toPtpn11
connects-toLztr1
connects-toKras
connects-toNf1
connects-toHeart
connects-toErk1 2
connects-toSchwannomatosis
connects-toMarfan Syndrome
connects-toNeurofibromatosis Type 1
connects-toLymphatic System
connects-toCardiomyocyte
connects-toPlatelet
connects-toRhabdomyosarcoma
connects-toNeuroblastoma
connects-toVon Willebrand Factor
connects-toAml
connects-toCardiovascular System
connects-toGrowth Hormone
connects-toOsteoporosis
connects-toNervous System
connects-toMusculoskeletal System
connects-toReproductive System
connects-toIgf 1
connects-toAll
connects-toEye
connects-toBraf
connects-toBone Marrow
connects-toMtor
connects-toAkt
connects-toEndothelial Cell
connects-toBrain
connects-toKidney
connects-toCalcium
connects-toMacrophage
connects-toPhoton
connects-toSkin
connects-toSpleen
connects-toLung
connects-toSmall Intestine
connects-toElectron
connects-toAntibody
connects-toErythrocyte
connects-toLiver
connects-toAttention Deficit Hyperactivity Disorder
connects-toCmml
connects-toOsteoclast
connects-toHeart Failure
connects-toThyroid
connects-toAutism Spectrum Disorder
connects-toSpred1
connects-toPulmonary Arterial Hypertension
connects-toWilms Tumor
connects-toStat3
connects-toNf Kb
connects-toMajor Depressive Disorder
connects-toStroke
connects-toCkd
connects-toSepsis
connects-toEndocrine System
connects-toIntegumentary System
connects-toGeneralized Anxiety Disorder
connects-toDigestive System
connects-toRespiratory System
connects-toRenal System
connects-toImmune System
connects-toStaphylococcus Aureus
connects-toBeta Blockers
connects-toTargeted Therapy
connects-toCarney Complex
connects-toTuberous Sclerosis Complex
connects-toCancer Chemotherapy
connects-toEndocardium
connects-toCardiac Conduction System
connects-toMyocardium
connects-toCortical Bone
connects-toHemophilia A
connects-toMyeloproliferative Neoplasms
connects-toAlveolus
connects-toPlacenta
connects-toTroponin Complex
connects-toBnp
connects-toGist
connects-toCalcineurin
connects-toVegf
connects-toCyclin D1
connects-toMyc
connects-toPik3Ca
connects-toPdgf
connects-toGsk 3B
connects-toSerca2A
connects-toAngiopoietin
connects-toTgf Beta
connects-toPten
connects-toBdnf
connects-toTestosterone
connects-toRankl
connects-toCalcium
connects-toNotch
connects-toConnexin43
connects-toE2F1
connects-toJak1 2
connects-toRyr2
connects-toRb1
connects-toGalectin 3
connects-toSmad4
connects-toCdkn2A
connects-toStat1
connects-toCgas Sting
connects-toFoxo
connects-toCdk4 6
connects-toS100A8 A9
connects-toHif 1Alpha
connects-toSrc Kinase
connects-toDnmt3A
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toMdm2
connects-toCxcl12
connects-toIl 6
connects-toIl 33
connects-toPhospholamban
connects-toSclerostin
connects-toThyroid Hormones
connects-toBeta1 Adrenergic Receptor
connects-toAngiotensin Ii
connects-toMhc Class Ii
connects-toHemoglobin
connects-toAldosterone
connects-toNitric Oxide
connects-toFibrinogen
connects-toRenin
connects-toMagnesium
connects-toPotassium
connects-toCortical Bone
connects-toBrain
connects-toLeptin
connects-toIl 4
connects-toIl 13
connects-toIl 5
connects-toAdiponectin
connects-toResistin
connects-toIfn Gamma
connects-toIl 12
connects-toType I Interferon
connects-toIl 17A
connects-toIl 23
connects-toIge
connects-toT Helper Cell
connects-toMast Cell
connects-toComplement C3
connects-toPeriostin
connects-toErythropoietin
connects-toHistamine
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toMelatonin
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toCopper
connects-toZinc
connects-toPhosphorus
connects-toIron
connects-toCarbon
connects-toChloride
connects-toNitrogen
connects-toHydrogen
connects-toOxygen
connects-toSulfur
connects-toPd 1
connects-toGlp 1
connects-toWnt Beta Catenin
connects-toIl 2
connects-toFibronectin
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toMyostatin
connects-toCortisol