Atlas One · Host Biology · Scale 07 — System

Schwannomatosis

Schwannomatosis is caused by germline SMARCB1 (~40%) or LZTR1 (~30%) mutations; multiple peripheral schwannomas WITHOUT bilateral vestibular schwannomas; chronic pain is the hallmark; distinct from NF2; treatment: surgical resection for symptomatic tumors.

Also known as: schwannomatosis, multiple schwannomatosis, SMARCB1 schwannomatosis, LZTR1 schwannomatosis, schwannomatosis type 1, schwannomatosis type 2, sporadic schwannomatosis, schwannomatosis NF2-negative, hereditary schwannomatosis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
schwannomatosis

Schwannomatosis

Schwannomatosis is caused by germline SMARCB1 (~40%) or LZTR1 (~30%) mutations; multiple peripheral schwannomas WITHOUT bilateral vestibular schwannomas; chronic pain is the hallmark; distinct from NF2; treatment: surgical resection for symptomatic tumors.

Entry Metadata

FieldValue
IDschwannomatosis
NameSchwannomatosis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toLztr1 connects-toSmarcb1 connects-toNeurofibromatosis Type 2 connects-toAtypical Teratoid Rhabdoid Tumor connects-toNf2 connects-toNoonan Syndrome connects-toPeripheral Nerve connects-toMpnst connects-toNeurofibromatosis Type 1 connects-toNervous System connects-toMeningioma connects-toNeuropathic Pain connects-toSynovial Sarcoma connects-toChordoma connects-toLi Fraumeni Syndrome connects-toEwing Sarcoma connects-toNeuron connects-toBrain connects-toFibroblast connects-toSkin connects-toPhoton connects-toMusculoskeletal System connects-toErk1 2 connects-toOligodendrocyte connects-toMtor connects-toKras connects-toYap1 connects-toMacrophage connects-toTnf Alpha connects-toPdgf connects-toMast Cell connects-toSodium connects-toEndothelial Cell connects-toSynapse connects-toElectron connects-toSubstance P connects-toCalcium connects-toCollagen connects-toAkt connects-toPotassium connects-toAntibody connects-toSerotonin connects-toLarge Intestine connects-toEzh2 connects-toReproductive System connects-toRegulatory T Cell connects-toGlutamate connects-toBradykinin connects-toVegf connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toMajor Depressive Disorder connects-toOpioid Use Disorder connects-toFibromyalgia connects-toInsomnia Disorder connects-toGeneralized Anxiety Disorder connects-toOsteoporosis connects-toWound Healing connects-toDigestive System connects-toCkd connects-toIntegumentary System connects-toEndocrine System connects-toRespiratory System connects-toRenal System connects-toCardiovascular System connects-toImmune System connects-toIbuprofen connects-toCarney Complex connects-toCurcumin connects-toTargeted Therapy connects-toDexamethasone connects-toTuberous Sclerosis Complex connects-toRenal Cell Carcinoma connects-toMesothelioma connects-toGuillain Barre connects-toNeuropathic Pain connects-toAxonal Transport connects-toFibrosis connects-toOvarian Clear Cell Carcinoma connects-toCidp connects-toNeuromuscular Junction connects-toProstaglandins connects-toCdk4 6 connects-toNotch connects-toCyclin D1 connects-toMyc connects-toHif 1Alpha connects-toNtrk connects-toCgrp connects-toCcl2 connects-toKit connects-toCxcl12 connects-toSrc Kinase connects-toEgfr connects-toPik3Ca connects-toIl 6 connects-toE2F1 connects-toPten connects-toTgf Beta connects-toRb1 connects-toJak1 2 connects-toTlr4 connects-toGalectin 3 connects-toSmad4 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toAutophagy connects-toArid1A connects-toDnmt3A connects-toAmpk connects-toCcr5 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toMu Opioid Receptor connects-toCalcium connects-toAxl Receptor connects-toNitric Oxide connects-toMhc Class Ii connects-toEstrogen connects-toT Cytotoxic Cell connects-toIl 10 connects-toHistamine connects-toIl 4 connects-toIl 13 connects-toXanthine Oxidase connects-toMagnesium connects-toProton connects-toIl 5 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 23 connects-toIge connects-toDendritic Cell connects-toT Helper Cell connects-toPlasma Cell connects-toNatural Killer Cell connects-toB Cell connects-toComplement C3 connects-toC5Ar1 connects-toTslp connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toComplement C5 connects-toFactor H connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toCopper connects-toZinc connects-toIron connects-toPhosphorus connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCalcitonin connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine