Atlas One · Host Biology · Scale 07 — System

Chordoma

Chordoma arises from notochordal remnants; skull base (~35%), sacrococcygeal (~50%), mobile spine (~15%); TBXT overexpression in >95%; physaliferous cell histology; proton RT + surgery standard; no FDA-approved systemic agent; imatinib, sorafenib, mTOR inhibitors active.

Also known as: chordoma, skull base chordoma, sacral chordoma, clival chordoma, spinal chordoma, brachyury chordoma, notochordal tumor, chordoma TBXT, physaliferous cell tumor, chordoma dedifferentiated

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
chordoma

Chordoma

Chordoma arises from notochordal remnants; skull base (~35%), sacrococcygeal (~50%), mobile spine (~15%); TBXT overexpression in >95%; physaliferous cell histology; proton RT + surgery standard; no FDA-approved systemic agent; imatinib, sorafenib, mTOR inhibitors active.

Entry Metadata

FieldValue
IDchordoma
NameChordoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTbxt connects-toMtor connects-toFgfr connects-toPdgf connects-toPten connects-toCdk4 6 connects-toCdkn2A connects-toEwing Sarcoma connects-toMusculoskeletal System connects-toBrain connects-toPhoton connects-toOsteosarcoma connects-toOsteoblast connects-toMeningioma connects-toFibroblast connects-toSynovial Sarcoma connects-toEgfr connects-toNeuron connects-toCollagen connects-toProton connects-toNervous System connects-toCarbon connects-toLung connects-toImmune System connects-toOxygen connects-toOsteoclast connects-toVegf connects-toP53 connects-toAkt connects-toMet connects-toT Cytotoxic Cell connects-toCalcium connects-toMacrophage connects-toLarge Intestine connects-toPeripheral Nerve connects-toLiver connects-toEndothelial Cell connects-toElectron connects-toBone Marrow connects-toEye connects-toAntibody connects-toReproductive System connects-toSmooth Muscle Cell connects-toTuberous Sclerosis Complex connects-toRegulatory T Cell connects-toHydrogen connects-toSmarcb1 connects-toAtypical Teratoid Rhabdoid Tumor connects-toNatural Killer Cell connects-toYap1 connects-toNeuropathic Pain connects-toMultiple Myeloma connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toWound Healing connects-toStroke connects-toCkd connects-toDigestive System connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toRenal System connects-toCardiovascular System connects-toRespiratory System connects-toIntegumentary System connects-toLymphatic System connects-toStreptococcus Pneumoniae connects-toTargeted Therapy connects-toRhabdomyosarcoma connects-toCortical Bone connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toAxonal Transport connects-toAlveolus connects-toSchwannomatosis connects-toHepatic Lobule connects-toRenal Cell Carcinoma connects-toOvarian Clear Cell Carcinoma connects-toNsclc connects-toEzh2 connects-toKit connects-toTert connects-toHif 1Alpha connects-toMyc connects-toCyclin D1 connects-toRankl connects-toIgf 1 connects-toCcl2 connects-toCxcl12 connects-toNotch connects-toCaspase 3 connects-toPerforin connects-toWnt Beta Catenin connects-toTgf Beta connects-toErk1 2 connects-toPik3Ca connects-toE2F1 connects-toRb1 connects-toJak1 2 connects-toBcl 2 connects-toGalectin 3 connects-toSmad4 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toGsk 3B connects-toSrc Kinase connects-toMdm2 connects-toS100A8 A9 connects-toDnmt3A connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toComplement C3 connects-toIl 17A connects-toCalcineurin connects-toOsteopontin connects-toMhc Class Ii connects-toPd 1 connects-toIl 2 connects-toT Helper Cell connects-toIl 10 connects-toNitric Oxide connects-toProstaglandins connects-toXanthine Oxidase connects-toIl 4 connects-toIl 13 connects-toPhoton connects-toOsteoblast connects-toCopper connects-toZinc connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNeutrophil connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toDendritic Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toC1 Esterase Inhibitor connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toMagnesium connects-toPhosphorus connects-toSodium connects-toPotassium connects-toIron connects-toChloride connects-toNitrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toCortisol

Sources