Atlas One · Host Biology · Scale 03 — Molecular

TBXT

TBXT (brachyury) is a T-box TF specifying notochordal lineage; overexpression/amplification defines chordoma (>95%); tandem TBXT duplication causes familial chordoma; TBXT is a lineage dependency factor; EZH2, FGFR, and mTOR inhibitors are active in TBXT-driven chordoma.

Also known as: TBXT, brachyury, T gene, T-box transcription factor T, chordoma brachyury, notochordal transcription factor, T gene chordoma, TBXT amplification, familial chordoma gene

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
tbxt

TBXT

TBXT (brachyury) is a T-box TF specifying notochordal lineage; overexpression/amplification defines chordoma (>95%); tandem TBXT duplication causes familial chordoma; TBXT is a lineage dependency factor; EZH2, FGFR, and mTOR inhibitors are active in TBXT-driven chordoma.

Entry Metadata

FieldValue
IDtbxt
NameTBXT
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toWnt Beta Catenin connects-toMtor connects-toFgfr connects-toPdgf

Sources