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pdgf
PDGF
Growth factor family (PDGF-AA/AB/BB) signaling via PDGFR-alpha/beta → RAS-MAPK and PI3K-AKT → fibroblast and smooth muscle proliferation. Drives cancer stroma fibrosis with TGF-beta; imatinib and sunitinib target PDGFR in GIST, systemic mastocytosis, and dermatofibrosarcoma.
Entry Metadata
| Field | Value |
|---|---|
| ID | pdgf |
| Name | PDGF |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Heldin CH, Östman A, Rönnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1998;1378(1):F79-F113. · PubMed 9739761
- Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347(7):472-480. · PubMed 12181401
- Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22(10):1276-1312. · PubMed 18483217