Atlas One · Host Biology · Scale 07 — System

Synovial Sarcoma

Synovial sarcoma is defined by SS18-SSX1/SSX2 fusion (t(X;18)) → SMARCB1 displacement from BAF → EZH2 dependency; ~800/year USA; biphasic/monophasic histology; TLE1 IHC positive; ifosfamide-based chemotherapy; tazemetostat (SARC057 ORR ~22%) and trabectedin active.

Also known as: synovial sarcoma, SS18-SSX sarcoma, biphasic synovial sarcoma, monophasic synovial sarcoma, t(X;18) sarcoma, TLE1-positive sarcoma, translocation sarcoma SYT-SSX, synovial cell sarcoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
synovial-sarcoma

Synovial Sarcoma

Synovial sarcoma is defined by SS18-SSX1/SSX2 fusion (t(X;18)) → SMARCB1 displacement from BAF → EZH2 dependency; ~800/year USA; biphasic/monophasic histology; TLE1 IHC positive; ifosfamide-based chemotherapy; tazemetostat (SARC057 ORR ~22%) and trabectedin active.

Entry Metadata

FieldValue
IDsynovial-sarcoma
NameSynovial Sarcoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSs18 connects-toEzh2 connects-toSmarcb1 connects-toCdkn2A connects-toVegf connects-toPd 1 connects-toWnt Beta Catenin connects-toAtypical Teratoid Rhabdoid Tumor connects-toMusculoskeletal System connects-toLung connects-toSchwannomatosis connects-toEwing Sarcoma connects-toFibroblast connects-toRhabdomyosarcoma connects-toMpnst connects-toPhoton connects-toP53 connects-toTert connects-toLi Fraumeni Syndrome connects-toImmune System connects-toDendritic Cell connects-toHeart connects-toT Cytotoxic Cell connects-toMacrophage connects-toIgf 1 connects-toArid1A connects-toRegulatory T Cell connects-toMtor connects-toOxygen connects-toBrain connects-toAkt connects-toCalcium connects-toLiver connects-toFibrosis connects-toElectron connects-toBone Marrow connects-toKidney connects-toCollagen connects-toNeuron connects-toMagnesium connects-toAntibody connects-toNeutrophil connects-toErythrocyte connects-toCardiomyocyte connects-toReproductive System connects-toHif 1Alpha connects-toBcl 2 connects-toEgfr connects-toNatural Killer Cell connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toCkd connects-toAml connects-toAnemia Of Chronic Disease connects-toHeart Failure connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toWound Healing connects-toNeuropathic Pain connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toVaricella Zoster Virus connects-toDigestive System connects-toLymphatic System connects-toRenal System connects-toCardiovascular System connects-toTargeted Therapy connects-toNervous System connects-toIntegumentary System connects-toCancer Chemotherapy connects-toCar T connects-toCheckpoint Inhibitors connects-toAlveolus connects-toGist connects-toOvarian Clear Cell Carcinoma connects-toDesmoid Tumor connects-toOsteosarcoma connects-toGerminal Center connects-toMelanoma connects-toCortical Bone connects-toPeripheral Nerve connects-toMyc connects-toCyclin D1 connects-toYap1 connects-toPdgf connects-toFgfr connects-toMet connects-toNotch connects-toTgf Beta connects-toCxcl12 connects-toCdk4 6 connects-toCcl2 connects-toCaspase 3 connects-toPik3Ca connects-toE2F1 connects-toSrc Kinase connects-toErk1 2 connects-toPten connects-toMdm2 connects-toRb1 connects-toKras connects-toJak1 2 connects-toGalectin 3 connects-toSmad4 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toS100A8 A9 connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toIl 6 connects-toCcr5 connects-toIl 1B connects-toCdkn1A connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toMhc Class Ii connects-toAxl Receptor connects-toAngiopoietin connects-toIl 2 connects-toTroponin Complex connects-toHemoglobin connects-toIl 10 connects-toXanthine Oxidase connects-toNitric Oxide connects-toIl 4 connects-toIron connects-toProton connects-toIl 13 connects-toMacrophage connects-toCortical Bone connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toC5Ar1 connects-toB Cell connects-toComplement C5 connects-toFactor H connects-toTslp connects-toErythropoietin connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toZinc connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toCortisol