Atlas One · Host Biology · Scale 03 — Molecular

SS18

SS18 (SYT) is a canonical BAF complex subunit; SS18-SSX1/SSX2 fusion (t(X;18)) displaces SMARCB1 from BAF → EZH2/PRC2 gains access → H3K27me3 → transcriptional silencing; SS18-SSX fusion defines synovial sarcoma (100%); tazemetostat and trabectedin target SS18-SSX-driven tumors.

Also known as: SS18, SYT, SS18-SSX, SS18-SSX1, SS18-SSX2, synovial sarcoma translocation, t(X;18), SS18 BAF complex, SWI/SNF SS18, SS18-SSX fusion

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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ss18

SS18

SS18 (SYT) is a canonical BAF complex subunit; SS18-SSX1/SSX2 fusion (t(X;18)) displaces SMARCB1 from BAF → EZH2/PRC2 gains access → H3K27me3 → transcriptional silencing; SS18-SSX fusion defines synovial sarcoma (100%); tazemetostat and trabectedin target SS18-SSX-driven tumors.

Entry Metadata

FieldValue
IDss18
NameSS18
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toSmarcb1 connects-toEzh2 connects-toMyc connects-toCdkn2A connects-toWnt Beta Catenin connects-toRb1 connects-toHif 1Alpha

Sources