Atlas One · Host Biology · Scale 07 — System

Ewing Sarcoma

Ewing sarcoma is an EWSR1-ETS fusion-driven small round blue cell tumor of bone/soft tissue; peak age 10-20 years; EWSR1-FLI1 ~85%; localized 5-year EFS ~60-70%; metastatic ~15-25%; VCD/IE or VIDE induction; local control by surgery ± RT; HDCT+auto-SCT for high-risk.

Also known as: Ewing sarcoma, ESFT, Ewing's sarcoma, primitive neuroectodermal tumor, PNET bone, EWS, Ewing sarcoma family tumors, extraskeletal Ewing

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
ewing-sarcoma

Ewing Sarcoma

Ewing sarcoma is an EWSR1-ETS fusion-driven small round blue cell tumor of bone/soft tissue; peak age 10-20 years; EWSR1-FLI1 ~85%; localized 5-year EFS ~60-70%; metastatic ~15-25%; VCD/IE or VIDE induction; local control by surgery ± RT; HDCT+auto-SCT for high-risk.

Entry Metadata

FieldValue
IDewing-sarcoma
NameEwing Sarcoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toEwsr1 connects-toMtor connects-toP53 connects-toErk1 2 connects-toPten connects-toCdkn2A connects-toVegf connects-toChordoma connects-toLung connects-toOsteosarcoma connects-toMusculoskeletal System connects-toRhabdomyosarcoma connects-toPhoton connects-toNeuroblastoma connects-toOsteoblast connects-toLi Fraumeni Syndrome connects-toBone Marrow connects-toFibroblast connects-toSynovial Sarcoma connects-toProton connects-toIgf 1 connects-toNervous System connects-toImmune System connects-toEndothelial Cell connects-toBrain connects-toOsteoclast connects-toNatural Killer Cell connects-toCalcium connects-toOxygen connects-toT Cytotoxic Cell connects-toMacrophage connects-toNeuron connects-toLiver connects-toPotassium connects-toPhosphorus connects-toPeripheral Nerve connects-toSkin connects-toElectron connects-toKidney connects-toLarge Intestine connects-toAntibody connects-toMagnesium connects-toReproductive System connects-toCardiomyocyte connects-toTert connects-toBladder Cancer connects-toStat3 connects-toRegulatory T Cell connects-toAtypical Teratoid Rhabdoid Tumor connects-toCyclin D1 connects-toDendritic Cell connects-toMds connects-toNf Kb connects-toSepsis connects-toVenous Thromboembolism connects-toAml connects-toHeart Failure connects-toAspergillus Fumigatus connects-toNeuropathic Pain connects-toCkd connects-toMajor Depressive Disorder connects-toWound Healing connects-toVaricella Zoster Virus connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toRenal System connects-toCardiovascular System connects-toEndocrine System connects-toDigestive System connects-toIntegumentary System connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toCar T connects-toCortical Bone connects-toCheckpoint Inhibitors connects-toLung Slice connects-toAxonal Transport connects-toBurkitt Lymphoma connects-toWilms Tumor connects-toAlveolus connects-toMyocardium connects-toBreast Cancer connects-toEzh2 connects-toMyc connects-toWnt Beta Catenin connects-toAkt connects-toPdgf connects-toHif 1Alpha connects-toRad51 connects-toRankl connects-toCcl2 connects-toCxcl12 connects-toCgas Sting connects-toCaspase 3 connects-toPerforin connects-toDnmt3A connects-toMdm2 connects-toPik3Ca connects-toCdk4 6 connects-toE2F1 connects-toRb1 connects-toJak1 2 connects-toBcl 2 connects-toGalectin 3 connects-toTgf Beta connects-toNfe2L2 connects-toStat1 connects-toSmad4 connects-toFoxo connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toAutophagy connects-toArid1A connects-toNotch connects-toAmpk connects-toCcr5 connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toCalcium connects-toInsulin Receptor connects-toMhc Class Ii connects-toBone Marrow connects-toHemoglobin connects-toTroponin Complex connects-toProstaglandins connects-toIl 10 connects-toXanthine Oxidase connects-toIl 4 connects-toIl 13 connects-toIron connects-toLeptin connects-toAdiponectin connects-toResistin connects-toAll connects-toHepcidin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toC1 Esterase Inhibitor connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toTestosterone connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toZinc connects-toChloride connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toIl 2 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources