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ewsr1
EWSR1
EWSR1 is an RNA-binding protein (FUS/EWS/TAF15 family); EWSR1-FLI1 t(11;22) fusion (~85% Ewing sarcoma) creates a neo-TF that activates GGAA microsatellite enhancers and drives neuroectodermal oncogenesis; EWSR1 also fuses with ATF1, DDIT3, and WT1 in other sarcomas.
Entry Metadata
| Field | Value |
|---|---|
| ID | ewsr1 |
| Name | EWSR1 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature. 1992;359(6391):162-165. · PubMed 1522903
- Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348(8):694-701. · PubMed 12594313