Atlas One · Host Biology · Scale 03 — Molecular

WT1

WT1 encodes a zinc-finger TF essential for kidney and gonadal development; germline mutations cause WAGR and Denys-Drash syndromes; mutations in ~10-15% sporadic Wilms tumor; WT1 overexpression in ~70-90% AML is an adverse prognostic marker and MRD target.

Also known as: WT1, Wilms tumor 1, WT1 gene, WT1 zinc finger, WT1 AML, WT1 Wilms tumor, WAGR WT1, Denys-Drash WT1

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
wt1

WT1

WT1 encodes a zinc-finger TF essential for kidney and gonadal development; germline mutations cause WAGR and Denys-Drash syndromes; mutations in ~10-15% sporadic Wilms tumor; WT1 overexpression in ~70-90% AML is an adverse prognostic marker and MRD target.

Entry Metadata

FieldValue
IDwt1
NameWT1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toP53 connects-toWnt Beta Catenin connects-toFlt3 connects-toMtor

Sources