Atlas One · Host Biology · Scale 07 — System

Bladder Cancer

Urothelial carcinoma of the bladder; FGFR3 mutations in ~25-35% and TERT promoter mutations in ~75%; PD-L1 expression guides immunotherapy. BCG is standard for non-muscle-invasive disease; enfortumab vedotin + pembrolizumab is first-line for metastatic urothelial carcinoma.

Also known as: urothelial carcinoma, bladder urothelial carcinoma, transitional cell carcinoma, NMIBC, MIBC, metastatic urothelial carcinoma, mUC, bladder TCC

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
bladder-cancer

Bladder Cancer

Urothelial carcinoma of the bladder; FGFR3 mutations in ~25-35% and TERT promoter mutations in ~75%; PD-L1 expression guides immunotherapy. BCG is standard for non-muscle-invasive disease; enfortumab vedotin + pembrolizumab is first-line for metastatic urothelial carcinoma.

Entry Metadata

FieldValue
IDbladder-cancer
NameBladder Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toFgfr connects-toPd 1 connects-toTert connects-toRb1 connects-toP53 connects-toLynch Syndrome connects-toArid1A connects-toKidney connects-toT Cytotoxic Cell connects-toCervical Cancer connects-toProstate Cancer connects-toRenal System connects-toImmune System connects-toRenal Cell Carcinoma connects-toNsclc connects-toMacrophage connects-toSmooth Muscle Cell connects-toHer2 connects-toVegf connects-toPhoton connects-toCdkn2A connects-toNsclc connects-toTuberculosis connects-toCarbon connects-toDendritic Cell connects-toEgfr connects-toNatural Killer Cell connects-toRegulatory T Cell connects-toNitrogen connects-toNf Kb connects-toNeutrophil connects-toIron connects-toLung connects-toFibroblast connects-toFibrosis connects-toEndothelial Cell connects-toLiver connects-toElectron connects-toBone Marrow connects-toLarge Intestine connects-toErythrocyte connects-toAntibody connects-toNeuron connects-toMycobacterium Tuberculosis connects-toReproductive System connects-toPlatelet connects-toPik3Ca connects-toB Cell connects-toHnscc connects-toCopd connects-toColorectal Cancer connects-toGut Microbiome connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toIron Deficiency Anemia connects-toCkd connects-toMajor Depressive Disorder connects-toNeuropathic Pain connects-toAnemia Of Chronic Disease connects-toAspergillus Fumigatus connects-toWound Healing connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toLymphatic System connects-toMusculoskeletal System connects-toNervous System connects-toRespiratory System connects-toCardiovascular System connects-toIntegumentary System connects-toCheckpoint Inhibitors connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toEndometrial Cancer connects-toCholangiocarcinoma connects-toCortical Bone connects-toAlveolus connects-toGerminal Center connects-toPancreatic Cancer connects-toAnca Vasculitis connects-toType 2 Diabetes connects-toHepatic Lobule connects-toSclc connects-toKras connects-toEzh2 connects-toAkt connects-toCyclin D1 connects-toHif 1Alpha connects-toMyc connects-toMtor connects-toCcl2 connects-toTlr4 connects-toCgas Sting connects-toCxcl12 connects-toIfn Gamma connects-toCaspase 3 connects-toCdh1 connects-toErk1 2 connects-toE2F1 connects-toPten connects-toMyd88 connects-toNfe2L2 connects-toTgf Beta connects-toWnt Beta Catenin connects-toJak1 2 connects-toGalectin 3 connects-toStat1 connects-toPerforin connects-toCdk4 6 connects-toFoxo connects-toSmad4 connects-toS100A8 A9 connects-toGsk 3B connects-toMdm2 connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toIl 1B connects-toIl 6 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toMhc Class Ii connects-toIl 2 connects-toAxl Receptor connects-toHemoglobin connects-toXanthine Oxidase connects-toIl 10 connects-toNitric Oxide connects-toProstaglandins connects-toTroponin Complex connects-toIl 4 connects-toIl 13 connects-toTuberculosis connects-toT Helper Cell connects-toLeptin connects-toAdiponectin connects-toResistin connects-toKidney connects-toDendritic Cell connects-toType I Interferon connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toMast Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toOsteopontin connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toCalcium connects-toMagnesium connects-toCopper connects-toZinc connects-toChloride connects-toHydrogen connects-toOxygen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin

Sources