Atlas One · Host Biology · Scale 07 — System

Cholangiocarcinoma

Cholangiocarcinoma includes intrahepatic (iCCA), perihilar, and distal subtypes; FGFR2 fusions and IDH1 mutations (~15% each) define iCCA. Gemcitabine/cisplatin+durvalumab (TOPAZ-1) is first-line; pemigatinib is approved for FGFR2-fusion iCCA; ivosidenib for IDH1-mutant CCA.

Also known as: cholangiocarcinoma, CCA, intrahepatic cholangiocarcinoma, iCCA, perihilar cholangiocarcinoma, Klatskin tumor, biliary tract cancer, BTC, bile duct cancer, FGFR2 fusion CCA

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cholangiocarcinoma

Cholangiocarcinoma

Cholangiocarcinoma includes intrahepatic (iCCA), perihilar, and distal subtypes; FGFR2 fusions and IDH1 mutations (~15% each) define iCCA. Gemcitabine/cisplatin+durvalumab (TOPAZ-1) is first-line; pemigatinib is approved for FGFR2-fusion iCCA; ivosidenib for IDH1-mutant CCA.

Entry Metadata

FieldValue
IDcholangiocarcinoma
NameCholangiocarcinoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toFgfr connects-toIdh1 connects-toPd 1 connects-toKras connects-toLiver connects-toBraf connects-toHer2 connects-toGastric Cancer connects-toHcc connects-toPancreatic Cancer connects-toInflammatory Bowel Disease connects-toColorectal Cancer connects-toFibroblast connects-toIdh Mutant Glioma connects-toHepatocyte connects-toT Cytotoxic Cell connects-toP53 connects-toMacrophage connects-toVegf connects-toFibrosis connects-toPhoton connects-toHepatitis C connects-toHepatitis B connects-toNash connects-toNeutrophil connects-toCopper connects-toNotch connects-toRegulatory T Cell connects-toSmall Intestine connects-toIl 6 connects-toOxygen connects-toPancreas connects-toEndothelial Cell connects-toCalcium connects-toLarge Intestine connects-toNatural Killer Cell connects-toTgf Beta connects-toElectron connects-toLung connects-toBone Marrow connects-toAntibody connects-toNeuron connects-toMagnesium connects-toGut Microbiome connects-toSpleen connects-toPlatelet connects-toEgfr connects-toDendritic Cell connects-toLynch Syndrome connects-toIdh2 connects-toSepsis connects-toMast Cell connects-toNf Kb connects-toStat3 connects-toVenous Thromboembolism connects-toCkd connects-toAnemia Of Chronic Disease connects-toMajor Depressive Disorder connects-toPrurigo Nodularis connects-toNeuropathic Pain connects-toAspergillus Fumigatus connects-toDigestive System connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toIntegumentary System connects-toLymphatic System connects-toNervous System connects-toRespiratory System connects-toImmune System connects-toRenal System connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toHepatitis B Virus connects-toCheckpoint Inhibitors connects-toHepatic Lobule connects-toAml connects-toAlveolus connects-toGerminal Center connects-toArid1A connects-toUveal Melanoma connects-toOvarian Clear Cell Carcinoma connects-toType 2 Diabetes connects-toYap1 connects-toMet connects-toNtrk connects-toPik3Ca connects-toHif 1Alpha connects-toMyc connects-toPdgf connects-toCcl2 connects-toAkt connects-toBap1 connects-toCxcl12 connects-toTlr4 connects-toCgas Sting connects-toCaspase 3 connects-toCholesterol connects-toErk1 2 connects-toMtor connects-toCdkn2A connects-toSmad4 connects-toJak1 2 connects-toMyd88 connects-toGalectin 3 connects-toPten connects-toWnt Beta Catenin connects-toStat1 connects-toEzh2 connects-toCdk4 6 connects-toFoxo connects-toPerforin connects-toS100A8 A9 connects-toGsk 3B connects-toMdm2 connects-toSrc Kinase connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toDnmt3A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toAxl Receptor connects-toIl 2 connects-toCollagen connects-toHemoglobin connects-toXanthine Oxidase connects-toPhoton connects-toIl 10 connects-toProstaglandins connects-toIl 4 connects-toMacrophage connects-toCopper connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNash connects-toHepatocyte connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toB Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toZinc connects-toIron connects-toPhosphorus connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine connects-toRenin