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cholangiocarcinoma
Cholangiocarcinoma
Cholangiocarcinoma includes intrahepatic (iCCA), perihilar, and distal subtypes; FGFR2 fusions and IDH1 mutations (~15% each) define iCCA. Gemcitabine/cisplatin+durvalumab (TOPAZ-1) is first-line; pemigatinib is approved for FGFR2-fusion iCCA; ivosidenib for IDH1-mutant CCA.
Entry Metadata
| Field | Value |
|---|---|
| ID | cholangiocarcinoma |
| Name | Cholangiocarcinoma |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toFgfr
connects-toIdh1
connects-toPd 1
connects-toKras
connects-toLiver
connects-toBraf
connects-toHer2
connects-toGastric Cancer
connects-toHcc
connects-toPancreatic Cancer
connects-toInflammatory Bowel Disease
connects-toColorectal Cancer
connects-toFibroblast
connects-toIdh Mutant Glioma
connects-toHepatocyte
connects-toT Cytotoxic Cell
connects-toP53
connects-toMacrophage
connects-toVegf
connects-toFibrosis
connects-toPhoton
connects-toHepatitis C
connects-toHepatitis B
connects-toNash
connects-toNeutrophil
connects-toCopper
connects-toNotch
connects-toRegulatory T Cell
connects-toSmall Intestine
connects-toIl 6
connects-toOxygen
connects-toPancreas
connects-toEndothelial Cell
connects-toCalcium
connects-toLarge Intestine
connects-toNatural Killer Cell
connects-toTgf Beta
connects-toElectron
connects-toLung
connects-toBone Marrow
connects-toAntibody
connects-toNeuron
connects-toMagnesium
connects-toGut Microbiome
connects-toSpleen
connects-toPlatelet
connects-toEgfr
connects-toDendritic Cell
connects-toLynch Syndrome
connects-toIdh2
connects-toSepsis
connects-toMast Cell
connects-toNf Kb
connects-toStat3
connects-toVenous Thromboembolism
connects-toCkd
connects-toAnemia Of Chronic Disease
connects-toMajor Depressive Disorder
connects-toPrurigo Nodularis
connects-toNeuropathic Pain
connects-toAspergillus Fumigatus
connects-toDigestive System
connects-toWound Healing
connects-toGeneralized Anxiety Disorder
connects-toIntegumentary System
connects-toLymphatic System
connects-toNervous System
connects-toRespiratory System
connects-toImmune System
connects-toRenal System
connects-toTargeted Therapy
connects-toCancer Chemotherapy
connects-toHepatitis B Virus
connects-toCheckpoint Inhibitors
connects-toHepatic Lobule
connects-toAml
connects-toAlveolus
connects-toGerminal Center
connects-toArid1A
connects-toUveal Melanoma
connects-toOvarian Clear Cell Carcinoma
connects-toType 2 Diabetes
connects-toYap1
connects-toMet
connects-toNtrk
connects-toPik3Ca
connects-toHif 1Alpha
connects-toMyc
connects-toPdgf
connects-toCcl2
connects-toAkt
connects-toBap1
connects-toCxcl12
connects-toTlr4
connects-toCgas Sting
connects-toCaspase 3
connects-toCholesterol
connects-toErk1 2
connects-toMtor
connects-toCdkn2A
connects-toSmad4
connects-toJak1 2
connects-toMyd88
connects-toGalectin 3
connects-toPten
connects-toWnt Beta Catenin
connects-toStat1
connects-toEzh2
connects-toCdk4 6
connects-toFoxo
connects-toPerforin
connects-toS100A8 A9
connects-toGsk 3B
connects-toMdm2
connects-toSrc Kinase
connects-toAmpk
connects-toAutophagy
connects-toCcr5
connects-toDnmt3A
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toCalcineurin
connects-toMhc Class Ii
connects-toAxl Receptor
connects-toIl 2
connects-toCollagen
connects-toHemoglobin
connects-toXanthine Oxidase
connects-toPhoton
connects-toIl 10
connects-toProstaglandins
connects-toIl 4
connects-toMacrophage
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connects-toIl 13
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toNash
connects-toHepatocyte
connects-toIfn Gamma
connects-toIl 12
connects-toType I Interferon
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toT Helper Cell
connects-toB Cell
connects-toC5Ar1
connects-toComplement C5
connects-toFactor H
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toMelatonin
connects-toTestosterone
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connects-toOxytocin
connects-toVasopressin
connects-toSerotonin
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connects-toIodine
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connects-toChloride
connects-toCarbon
connects-toHydrogen
connects-toNitrogen
connects-toGlp 1
connects-toAngiotensin Ii
connects-toRankl
connects-toFibronectin
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toEpinephrine
connects-toRenin
Sources
- Abou-Alfa GK, Macarulla T, Javle MM, et al. Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2020;21(6):796-807. · PubMed 32416072
- Oh DY, He AR, Qin S, et al. Durvalumab plus Gemcitabine and Cisplatin in Biliary Tract Cancer. NEJM Evidence. 2022;1(8):EVIDoa2200015. · PubMed 38319282