Atlas One · Host Biology · Scale 07 — System

Hepatitis B

HBV (hepadnavirus; RC-DNA; 3.2 kb) infects 296M people; replicates via pgRNA/reverse transcriptase; tenofovir/entecavir suppress but do not clear cccDNA; HBeAg seroconversion marks immune control; 50-55% of global HCC; functional cure (HBsAg loss) is emerging treatment goal.

Also known as: HBV, hepatitis B virus, chronic hepatitis B, CHB, HBsAg, HBeAg, cccDNA HBV, tenofovir HBV, entecavir, HBV cirrhosis, HBV HCC, hepadnavirus, Dane particle, hepatitis B vaccine, NTCP receptor

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hepatitis-b

Hepatitis B

HBV (hepadnavirus; RC-DNA; 3.2 kb) infects 296M people; replicates via pgRNA/reverse transcriptase; tenofovir/entecavir suppress but do not clear cccDNA; HBeAg seroconversion marks immune control; 50-55% of global HCC; functional cure (HBsAg loss) is emerging treatment goal.

Entry Metadata

FieldValue
IDhepatitis-b
NameHepatitis B
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCccdna connects-toCgas Sting connects-toNf Kb connects-toTgf Beta connects-toHcc connects-toHepatitis B Virus connects-toLiver connects-toHepatocyte connects-toHepatitis C connects-toP53 connects-toT Cytotoxic Cell connects-toHiv Aids connects-toMacrophage connects-toAnca Vasculitis connects-toCholangiocarcinoma connects-toNatural Killer Cell connects-toImmune System connects-toType I Interferon connects-toDendritic Cell connects-toNash connects-toB Cell connects-toFibrosis connects-toKidney connects-toPlacenta connects-toT Helper Cell connects-toRegulatory T Cell connects-toAlbumin connects-toImmunoglobulin G connects-toOxygen connects-toSpleen connects-toBrain connects-toIron connects-toPhoton connects-toSodium connects-toFibroblast connects-toElectron connects-toGlomerulus connects-toVitamin D connects-toAntibody connects-toNeuron connects-toSkin connects-toReproductive System connects-toLarge Intestine connects-toBone Marrow connects-toStat1 connects-toDlbcl connects-toPlatelet connects-toTert connects-toCtnnb1 connects-toCkd connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toAnemia Of Chronic Disease connects-toRheumatoid Arthritis connects-toMajor Depressive Disorder connects-toType 2 Diabetes connects-toOsteoporosis connects-toAplastic Anemia connects-toDigestive System connects-toNervous System connects-toGeneralized Anxiety Disorder connects-toRenal System connects-toIntegumentary System connects-toMusculoskeletal System connects-toCardiovascular System connects-toLymphatic System connects-toEndocrine System connects-toAdalimumab connects-toCorticosteroids connects-toRespiratory System connects-toHepatic Lobule connects-toCheckpoint Inhibitors connects-toMilk Thistle connects-toArterial Wall connects-toInflammatory Bowel Disease connects-toFollicular Lymphoma connects-toGerminal Center connects-toIga Nephropathy connects-toPancreatic Cancer connects-toPeripheral Nerve connects-toMultiple Myeloma connects-toCovid 19 Disease connects-toPd 1 connects-toMyc connects-toIl 6 connects-toPdgf connects-toTnf Alpha connects-toCcl2 connects-toIfn Gamma connects-toPerforin connects-toRig I connects-toVegf connects-toCaspase 3 connects-toIl 10 connects-toMavs connects-toIrf3 connects-toNlrp3 Inflammasome connects-toAkt connects-toErk1 2 connects-toCollagen connects-toJak1 2 connects-toMyd88 connects-toSmad4 connects-toGalectin 3 connects-toEzh2 connects-toMtor connects-toFoxo connects-toHif 1Alpha connects-toCdk4 6 connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toPik3Ca connects-toAutophagy connects-toDnmt3A connects-toAmpk connects-toCcr5 connects-toSrc Kinase connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toMhc Class Ii connects-toAxl Receptor connects-toGlucocorticoid Receptor connects-toIl 2 connects-toCtla 4 connects-toHepcidin connects-toXanthine Oxidase connects-toComplement C3 connects-toNitric Oxide connects-toIl 4 connects-toIl 17A connects-toIron connects-toIl 13 connects-toZinc connects-toBaff connects-toLeptin connects-toAdiponectin connects-toResistin connects-toHcc connects-toIl 12 connects-toIl 5 connects-toHepatitis B Virus connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toMagnesium connects-toIodine connects-toCopper connects-toPotassium connects-toCalcium connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toCarbon connects-toHydrogen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin

Sources