Atlas One · Host Biology · Scale 03 — Molecular

cccDNA

HBV cccDNA (covalently closed circular DNA; 3.2 kb) forms in hepatocyte nucleus as a minichromosome; template for all HBV RNAs; persists decades; not cleared by NRTIs; HBx transactivates cccDNA; cGAS senses HBV DNA; curative therapy requires cccDNA elimination.

Also known as: cccDNA, covalently closed circular DNA, HBV cccDNA, HBV minichromosome, HBV nuclear reservoir, HBV persistence, HBV epigenome, hepatitis B cccDNA

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cccdna

cccDNA

HBV cccDNA (covalently closed circular DNA; 3.2 kb) forms in hepatocyte nucleus as a minichromosome; template for all HBV RNAs; persists decades; not cleared by NRTIs; HBx transactivates cccDNA; cGAS senses HBV DNA; curative therapy requires cccDNA elimination.

Entry Metadata

FieldValue
IDcccdna
NamecccDNA
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHepatitis B connects-toCgas Sting connects-toP53 connects-toWnt Beta Catenin connects-toMavs

Sources