Atlas One · Host Biology · Scale 03 — Molecular

MAVS

MAVS (mitochondrial antiviral signaling protein; VISA/IPS-1/CARDIF) is the central adaptor for RIG-I and MDA5 RNA virus sensing: 5′ppp/dsRNA → RIG-I/MDA5 → MAVS CARD-CARD interaction → filamentous MAVS aggregation → TBK1/IKKε → IRF3 → IFN-β + NF-κB; HCV NS3/4A cleaves MAVS.

Also known as: MAVS, IPS-1, VISA, CARDIF, mitochondrial antiviral signaling protein, RIG-I signaling, MDA5 pathway, MAVS signaling, RIG-I/MDA5, innate RNA sensing, antiviral CARD adaptor

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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mavs

MAVS

MAVS (mitochondrial antiviral signaling protein; VISA/IPS-1/CARDIF) is the central adaptor for RIG-I and MDA5 RNA virus sensing: 5′ppp/dsRNA → RIG-I/MDA5 → MAVS CARD-CARD interaction → filamentous MAVS aggregation → TBK1/IKKε → IRF3 → IFN-β + NF-κB; HCV NS3/4A cleaves MAVS.

Entry Metadata

FieldValue
IDmavs
NameMAVS
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toDengue Fever connects-toType I Interferon connects-toCgas Sting connects-toNf Kb

Sources