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follicular-lymphoma
Follicular Lymphoma
Follicular lymphoma is the most common indolent B-cell lymphoma; t(14;18) BCL-2-IGH in ~85% drives apoptosis resistance; EZH2 Y641 in ~25% silences tumor suppressors. Rituximab+bendamustine or R-CHOP are standard; tazemetostat is approved for EZH2-mutant relapsed/refractory FL.
Entry Metadata
| Field | Value |
|---|---|
| ID | follicular-lymphoma |
| Name | Follicular Lymphoma |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toBcl 2
connects-toCd20
connects-toMyc
connects-toNf Kb
connects-toEzh2
connects-toDlbcl
connects-toPd 1
connects-toMantle Cell Lymphoma
connects-toB Cell
connects-toSpleen
connects-toCll
connects-toLymphatic System
connects-toGerminal Center
connects-toHodgkin Lymphoma
connects-toBurkitt Lymphoma
connects-toMultiple Myeloma
connects-toT Helper Cell
connects-toPlasma Cell
connects-toImmune System
connects-toBone Marrow
connects-toPhoton
connects-toNervous System
connects-toDendritic Cell
connects-toT Cytotoxic Cell
connects-toLiver
connects-toMtor
connects-toRegulatory T Cell
connects-toNatural Killer Cell
connects-toMacrophage
connects-toVegf
connects-toCalcium
connects-toIron
connects-toSmall Intestine
connects-toEndothelial Cell
connects-toPhosphorus
connects-toSkin
connects-toIl 4
connects-toElectron
connects-toEye
connects-toLarge Intestine
connects-toAntibody
connects-toNeuron
connects-toHeart
connects-toHepatitis B
connects-toAkt
connects-toNeutrophil
connects-toBaff
connects-toMast Cell
connects-toCytokine Storm
connects-toCxcl12
connects-toEpstein Barr Virus
connects-toSepsis
connects-toStat3
connects-toVenous Thromboembolism
connects-toAnemia Of Chronic Disease
connects-toHepatitis B Virus
connects-toPneumocystis Jirovecii
connects-toHeart Failure
connects-toNeuropathic Pain
connects-toAspergillus Fumigatus
connects-toMajor Depressive Disorder
connects-toDigestive System
connects-toVaricella Zoster Virus
connects-toGeneralized Anxiety Disorder
connects-toRenal System
connects-toRespiratory System
connects-toIntegumentary System
connects-toMusculoskeletal System
connects-toCardiovascular System
connects-toReproductive System
connects-toCancer Chemotherapy
connects-toTargeted Therapy
connects-toCar T
connects-toCheckpoint Inhibitors
connects-toIntestinal Epithelium
connects-toWaldenstrom Macroglobulinemia
connects-toP53
connects-toRheumatoid Arthritis
connects-toMyocardium
connects-toHepatitis C
connects-toSjogrens Syndrome
connects-toGlomerulus
connects-toHepatitis C Virus
connects-toFoxo1
connects-toPik3Ca
connects-toCdk4 6
connects-toIl 6
connects-toHif 1Alpha
connects-toCcl2
connects-toTgf Beta
connects-toTert
connects-toCaspase 3
connects-toBtk
connects-toJak1 2
connects-toPerforin
connects-toComplement C3
connects-toDnmt3A
connects-toPten
connects-toE2F1
connects-toCdkn2A
connects-toIl 10
connects-toRb1
connects-toErk1 2
connects-toGalectin 3
connects-toSmad4
connects-toCgas Sting
connects-toStat1
connects-toFoxo
connects-toKras
connects-toGsk 3B
connects-toS100A8 A9
connects-toMdm2
connects-toSrc Kinase
connects-toAutophagy
connects-toArid1A
connects-toAmpk
connects-toCcr5
connects-toNotch
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toCalcineurin
connects-toAdenosine
connects-toOsteopontin
connects-toMhc Class Ii
connects-toIl 2
connects-toCtla 4
connects-toHemoglobin
connects-toTroponin Complex
connects-toXanthine Oxidase
connects-toIl 13
connects-toNitric Oxide
connects-toProstaglandins
connects-toLeptin
connects-toAdiponectin
connects-toHepcidin
connects-toResistin
connects-toType I Interferon
connects-toZinc
connects-toIfn Gamma
connects-toIl 12
connects-toSelenium
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toComplement C5
connects-toC5Ar1
connects-toVitamin D
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toTransferrin
connects-toPeriostin
connects-toCollagen
connects-toFibronectin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toMelatonin
connects-toTestosterone
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSerotonin
connects-toIodine
connects-toSodium
connects-toMagnesium
connects-toCopper
connects-toPotassium
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toCarbon
connects-toHydrogen
connects-toOxygen
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toFgfr
connects-toEpinephrine
connects-toRenin
Sources
- Marcus R, Davies A, Ando K, et al. Obinutuzumab for the first-line treatment of follicular lymphoma. N Engl J Med. 2017;377(14):1331-1344. · PubMed 28976863
- Morschhauser F, Tilly H, Chaidos A, et al. Tazemetostat for patients with relapsed or refractory follicular lymphoma (E7438-G-003): a multicentre, open-label, single-arm, phase 2 trial. Lancet Oncol. 2020;21(11):1433-1442. · PubMed 33035457