Atlas One · Host Biology · Scale 07 — System

Sjögren's Syndrome

Primary Sjögren's syndrome (pSS): systemic lymphocytic exocrinopathy; xerostomia, xerophthalmia, anti-Ro/SSA (80%); type I IFN signature; 40× elevated lymphoma risk; BAFF drives B-cell hyperactivation. Ianalumab (anti-BAFFR; TWINSS 2023) and rituximab are active biologics.

Also known as: Sjögren's syndrome, primary Sjögren's syndrome, pSS, Sjogrens, sicca syndrome, autoimmune exocrinopathy, anti-Ro/SSA disease

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
sjogrens-syndrome

Sjögren's Syndrome

Primary Sjögren's syndrome (pSS): systemic lymphocytic exocrinopathy; xerostomia, xerophthalmia, anti-Ro/SSA (80%); type I IFN signature; 40× elevated lymphoma risk; BAFF drives B-cell hyperactivation. Ianalumab (anti-BAFFR; TWINSS 2023) and rituximab are active biologics.

Entry Metadata

FieldValue
IDsjogrens-syndrome
NameSjögren's Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toBaff connects-toType I Interferon connects-toIl 6 connects-toCd20 connects-toB Cell connects-toRegulatory T Cell connects-toDlbcl connects-toSystemic Sclerosis connects-toEye connects-toSystemic Lupus Erythematosus connects-toRheumatoid Arthritis connects-toPlasma Cell connects-toFollicular Lymphoma connects-toMantle Cell Lymphoma connects-toLymphatic System connects-toDermatomyositis connects-toT Helper Cell connects-toThyroid connects-toPeripheral Nerve connects-toKidney connects-toLung connects-toNervous System connects-toPlacenta connects-toDendritic Cell connects-toMhc Class Ii connects-toAcetylcholine connects-toComplement C3 connects-toMacrophage connects-toPotassium connects-toBrain connects-toT Cytotoxic Cell connects-toHydrogen connects-toSkin connects-toGerminal Center connects-toPhoton connects-toPancreas connects-toVitamin D connects-toAntibody connects-toLiver connects-toErythrocyte connects-toNeutrophil connects-toStomach connects-toReproductive System connects-toStat1 connects-toWaldenstrom Macroglobulinemia connects-toChloride connects-toCandida Albicans connects-toJak1 2 connects-toRenal System connects-toStat3 connects-toNf Kb connects-toVenous Thromboembolism connects-toCkd connects-toFibromyalgia connects-toAnemia Of Chronic Disease connects-toNeuropathic Pain connects-toPulmonary Arterial Hypertension connects-toMajor Depressive Disorder connects-toDigestive System connects-toIntegumentary System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toEndocrine System connects-toImmune System connects-toCardiovascular System connects-toMusculoskeletal System connects-toHepatitis C Virus connects-toCorticosteroids connects-toEpstein Barr Virus connects-toOmega 3 Fatty Acids connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toFibrosis connects-toNmo connects-toPemphigus Vulgaris connects-toGuillain Barre connects-toAlveolus connects-toGlomerulus connects-toCidp connects-toCardiac Conduction System connects-toPtcl connects-toCovid 19 Disease connects-toIfn Gamma connects-toIl 17A connects-toAquaporin 4 connects-toTnf Alpha connects-toIl 1B connects-toNlrp3 Inflammasome connects-toBtk connects-toCtla 4 connects-toCcl2 connects-toCxcl12 connects-toBcl 2 connects-toIl 33 connects-toCaspase 3 connects-toIl 12 connects-toComplement C5 connects-toMyd88 connects-toCgas Sting connects-toMyc connects-toIl 23 connects-toTlr4 connects-toPerforin connects-toAkt connects-toMtor connects-toGalectin 3 connects-toSmad4 connects-toFoxo connects-toErk1 2 connects-toGsk 3B connects-toS100A8 A9 connects-toHif 1Alpha connects-toPik3Ca connects-toSrc Kinase connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toDnmt3A connects-toCalcineurin connects-toIl 10 connects-toAdenosine connects-toImmunoglobulin G connects-toEstrogen connects-toSecretory Iga connects-toHemoglobin connects-toIl 4 connects-toHeart connects-toIl 13 connects-toIl 2 connects-toXanthine Oxidase connects-toProstaglandins connects-toIron connects-toNitric Oxide connects-toHepcidin connects-toVegf connects-toCalcium connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNatural Killer Cell connects-toIl 5 connects-toIge connects-toMast Cell connects-toTslp connects-toSelenium connects-toIl 31 connects-toC5Ar1 connects-toPeriostin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toTestosterone connects-toSerotonin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toSulfur connects-toNitrogen connects-toOxygen connects-toCarbon connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin