This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
sjogrens-syndrome
Sjögren's Syndrome
Primary Sjögren's syndrome (pSS): systemic lymphocytic exocrinopathy; xerostomia, xerophthalmia, anti-Ro/SSA (80%); type I IFN signature; 40× elevated lymphoma risk; BAFF drives B-cell hyperactivation. Ianalumab (anti-BAFFR; TWINSS 2023) and rituximab are active biologics.
Entry Metadata
| Field | Value |
|---|---|
| ID | sjogrens-syndrome |
| Name | Sjögren's Syndrome |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toBaff
connects-toType I Interferon
connects-toIl 6
connects-toCd20
connects-toB Cell
connects-toRegulatory T Cell
connects-toDlbcl
connects-toSystemic Sclerosis
connects-toEye
connects-toSystemic Lupus Erythematosus
connects-toRheumatoid Arthritis
connects-toPlasma Cell
connects-toFollicular Lymphoma
connects-toMantle Cell Lymphoma
connects-toLymphatic System
connects-toDermatomyositis
connects-toT Helper Cell
connects-toThyroid
connects-toPeripheral Nerve
connects-toKidney
connects-toLung
connects-toNervous System
connects-toPlacenta
connects-toDendritic Cell
connects-toMhc Class Ii
connects-toAcetylcholine
connects-toComplement C3
connects-toMacrophage
connects-toPotassium
connects-toBrain
connects-toT Cytotoxic Cell
connects-toHydrogen
connects-toSkin
connects-toGerminal Center
connects-toPhoton
connects-toPancreas
connects-toVitamin D
connects-toAntibody
connects-toLiver
connects-toErythrocyte
connects-toNeutrophil
connects-toStomach
connects-toReproductive System
connects-toStat1
connects-toWaldenstrom Macroglobulinemia
connects-toChloride
connects-toCandida Albicans
connects-toJak1 2
connects-toRenal System
connects-toStat3
connects-toNf Kb
connects-toVenous Thromboembolism
connects-toCkd
connects-toFibromyalgia
connects-toAnemia Of Chronic Disease
connects-toNeuropathic Pain
connects-toPulmonary Arterial Hypertension
connects-toMajor Depressive Disorder
connects-toDigestive System
connects-toIntegumentary System
connects-toGeneralized Anxiety Disorder
connects-toRespiratory System
connects-toEndocrine System
connects-toImmune System
connects-toCardiovascular System
connects-toMusculoskeletal System
connects-toHepatitis C Virus
connects-toCorticosteroids
connects-toEpstein Barr Virus
connects-toOmega 3 Fatty Acids
connects-toCancer Chemotherapy
connects-toTargeted Therapy
connects-toFibrosis
connects-toNmo
connects-toPemphigus Vulgaris
connects-toGuillain Barre
connects-toAlveolus
connects-toGlomerulus
connects-toCidp
connects-toCardiac Conduction System
connects-toPtcl
connects-toCovid 19 Disease
connects-toIfn Gamma
connects-toIl 17A
connects-toAquaporin 4
connects-toTnf Alpha
connects-toIl 1B
connects-toNlrp3 Inflammasome
connects-toBtk
connects-toCtla 4
connects-toCcl2
connects-toCxcl12
connects-toBcl 2
connects-toIl 33
connects-toCaspase 3
connects-toIl 12
connects-toComplement C5
connects-toMyd88
connects-toCgas Sting
connects-toMyc
connects-toIl 23
connects-toTlr4
connects-toPerforin
connects-toAkt
connects-toMtor
connects-toGalectin 3
connects-toSmad4
connects-toFoxo
connects-toErk1 2
connects-toGsk 3B
connects-toS100A8 A9
connects-toHif 1Alpha
connects-toPik3Ca
connects-toSrc Kinase
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toDnmt3A
connects-toCalcineurin
connects-toIl 10
connects-toAdenosine
connects-toImmunoglobulin G
connects-toEstrogen
connects-toSecretory Iga
connects-toHemoglobin
connects-toIl 4
connects-toHeart
connects-toIl 13
connects-toIl 2
connects-toXanthine Oxidase
connects-toProstaglandins
connects-toIron
connects-toNitric Oxide
connects-toHepcidin
connects-toVegf
connects-toCalcium
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toNatural Killer Cell
connects-toIl 5
connects-toIge
connects-toMast Cell
connects-toTslp
connects-toSelenium
connects-toIl 31
connects-toC5Ar1
connects-toPeriostin
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toTransferrin
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toMelatonin
connects-toProlactin
connects-toOxytocin
connects-toTestosterone
connects-toSerotonin
connects-toVasopressin
connects-toIodine
connects-toSodium
connects-toMagnesium
connects-toCopper
connects-toZinc
connects-toPhosphorus
connects-toSulfur
connects-toNitrogen
connects-toOxygen
connects-toCarbon
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
Sources
- Shiboski CH, Shiboski SC, Seror R, et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome. Arthritis Rheumatol. 2017;69(1):35-45. · PubMed 27785888
- Dörner T, Bowman SJ, Fox R, et al. Ianalumab (VAY736) in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial (TWINSS). Lancet. 2023;402(10400):477-489. · PubMed 37499657
- Seror R, Ravaud P, Mariette X, et al. EULAR Sjögren's Syndrome Disease Activity Index and Patient Reported Index. Ann Rheum Dis. 2019;78(11):1554-1560. · PubMed 31462415