Atlas One · Host Biology · Scale 07 — System

Peripheral T-cell Lymphoma

PTCLs are aggressive T/NK-cell lymphomas (~10-15% of NHL); major subtypes PTCL-NOS (~25%), AITL (~20%), ALK+ ALCL (~7%), ALK- ALCL (~8%); AITL driven by TET2+DNMT3A+RHOA G17V; brentuximab vedotin+CHP is standard for CD30+ PTCL (ECHELON-2); 5-year OS ~30-50%.

Also known as: PTCL, peripheral T-cell lymphoma, AITL, angioimmunoblastic T-cell lymphoma, ALCL, anaplastic large cell lymphoma, ALK+ ALCL, ALK- ALCL, T-cell lymphoma, PTCL-NOS

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
ptcl

Peripheral T-cell Lymphoma

PTCLs are aggressive T/NK-cell lymphomas (~10-15% of NHL); major subtypes PTCL-NOS (~25%), AITL (~20%), ALK+ ALCL (~7%), ALK- ALCL (~8%); AITL driven by TET2+DNMT3A+RHOA G17V; brentuximab vedotin+CHP is standard for CD30+ PTCL (ECHELON-2); 5-year OS ~30-50%.

Entry Metadata

FieldValue
IDptcl
NamePeripheral T-cell Lymphoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTet2 connects-toDnmt3A connects-toAlk connects-toPd 1 connects-toIdh2 connects-toStat3 connects-toCd30 connects-toPcnsl connects-toT Helper Cell connects-toSkin connects-toDlbcl connects-toHodgkin Lymphoma connects-toRegulatory T Cell connects-toEpstein Barr Virus connects-toMantle Cell Lymphoma connects-toFollicular Lymphoma connects-toNatural Killer Cell connects-toLymphatic System connects-toBone Marrow connects-toT Cytotoxic Cell connects-toSpleen connects-toImmune System connects-toThymus connects-toGerminal Center connects-toDendritic Cell connects-toVegf connects-toMacrophage connects-toIl 6 connects-toCalcium connects-toLarge Intestine connects-toNf Kb connects-toIron connects-toLiver connects-toEndothelial Cell connects-toPhoton connects-toSmall Intestine connects-toErythrocyte connects-toPlasma Cell connects-toB Cell connects-toNeuron connects-toAntibody connects-toNeutrophil connects-toKidney connects-toCardiomyocyte connects-toJak2 connects-toReproductive System connects-toIntestinal Epithelium connects-toMtor connects-toMds connects-toCytokine Storm connects-toSepsis connects-toNlrp3 Inflammasome connects-toVenous Thromboembolism connects-toPneumocystis Jirovecii connects-toAnemia Of Chronic Disease connects-toAspergillus Fumigatus connects-toHeart Failure connects-toMajor Depressive Disorder connects-toVaricella Zoster Virus connects-toCkd connects-toGeneralized Anxiety Disorder connects-toDigestive System connects-toIntegumentary System connects-toNervous System connects-toEndocrine System connects-toRespiratory System connects-toCardiovascular System connects-toMusculoskeletal System connects-toRenal System connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toBurkitt Lymphoma connects-toCar T connects-toAml connects-toNsclc connects-toCheckpoint Inhibitors connects-toCmml connects-toIdh Mutant Glioma connects-toHepatic Lobule connects-toSjogrens Syndrome connects-toRheumatoid Arthritis connects-toHiv Aids connects-toEzh2 connects-toIfn Gamma connects-toIl 2 connects-toTnf Alpha connects-toCyclin D1 connects-toHif 1Alpha connects-toJak1 2 connects-toTgf Beta connects-toCcl2 connects-toPik3Ca connects-toBcl 2 connects-toPerforin connects-toMyc connects-toPdgf connects-toIl 10 connects-toErk1 2 connects-toAkt connects-toE2F1 connects-toRb1 connects-toKras connects-toMyd88 connects-toGalectin 3 connects-toSmad4 connects-toPten connects-toStat1 connects-toCgas Sting connects-toCdk4 6 connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toSrc Kinase connects-toS100A8 A9 connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toLmp1 connects-toMhc Class Ii connects-toCaspase 3 connects-toImmunoglobulin G connects-toHemoglobin connects-toXanthine Oxidase connects-toTroponin Complex connects-toProton connects-toSecretory Iga connects-toIl 13 connects-toIl 4 connects-toNitric Oxide connects-toIl 5 connects-toIge connects-toPotassium connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIl 12 connects-toIl 23 connects-toIl 31 connects-toHistamine connects-toMast Cell connects-toTslp connects-toPeriostin connects-toComplement C5 connects-toComplement C3 connects-toC5Ar1 connects-toFactor H connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toProlactin connects-toOxytocin connects-toTestosterone connects-toSerotonin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine

Sources