Atlas One · Host Biology · Scale 07 — System

Primary CNS Lymphoma

PCNSL is ABC-DLBCL confined to CNS; MYD88 L265P ~90%, CD79B ~70%; high-dose methotrexate is the treatment backbone; ibrutinib shows ~50-60% ORR in R/R disease; 5-year OS ~30-40% with HDMTX-based therapy; vitreous IL-10 >10 pg/mL is pathognomonic.

Also known as: PCNSL, primary CNS lymphoma, primary central nervous system lymphoma, CNS lymphoma, cerebral lymphoma, vitreoretinal lymphoma, primary intraocular lymphoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
pcnsl

Primary CNS Lymphoma

PCNSL is ABC-DLBCL confined to CNS; MYD88 L265P ~90%, CD79B ~70%; high-dose methotrexate is the treatment backbone; ibrutinib shows ~50-60% ORR in R/R disease; 5-year OS ~30-40% with HDMTX-based therapy; vitreous IL-10 >10 pg/mL is pathognomonic.

Entry Metadata

FieldValue
IDpcnsl
NamePrimary CNS Lymphoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMyd88 connects-toPd 1 connects-toBtk connects-toIl 6 connects-toBrain connects-toB Cell connects-toEpstein Barr Virus connects-toPtcl connects-toDlbcl connects-toEye connects-toHiv Aids connects-toPhoton connects-toMicroglia connects-toGlioblastoma connects-toMeningioma connects-toMantle Cell Lymphoma connects-toImmune System connects-toGerminal Center connects-toMyc connects-toCd20 connects-toNervous System connects-toLymphatic System connects-toNf Kb connects-toT Cytotoxic Cell connects-toWaldenstrom Macroglobulinemia connects-toCxcl12 connects-toMacrophage connects-toRegulatory T Cell connects-toCalcium connects-toDendritic Cell connects-toAkt connects-toKidney connects-toEndothelial Cell connects-toPotassium connects-toBone Marrow connects-toSpleen connects-toPlasma Cell connects-toNeuron connects-toOligodendrocyte connects-toLiver connects-toAntibody connects-toCortisol connects-toNeutrophil connects-toStat3 connects-toReproductive System connects-toPlatelet connects-toBcl 2 connects-toAstrocyte connects-toBurkitt Lymphoma connects-toCytokine Storm connects-toSepsis connects-toVenous Thromboembolism connects-toToxoplasma Gondii connects-toEpilepsy connects-toCkd connects-toPneumocystis Jirovecii connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toVaricella Zoster Virus connects-toAnemia Of Chronic Disease connects-toGeneralized Anxiety Disorder connects-toEndocrine System connects-toDigestive System connects-toMusculoskeletal System connects-toRenal System connects-toRespiratory System connects-toIntegumentary System connects-toCardiovascular System connects-toTargeted Therapy connects-toHiv 1 connects-toCancer Chemotherapy connects-toCar T connects-toCheckpoint Inhibitors connects-toFollicular Lymphoma connects-toCll connects-toRheumatoid Arthritis connects-toHippocampus connects-toAxonal Transport connects-toMultiple Sclerosis connects-toCryptococcus Neoformans connects-toSystemic Lupus Erythematosus connects-toArterial Wall connects-toFoxo1 connects-toCdkn2A connects-toEzh2 connects-toCyclin D1 connects-toVegf connects-toHif 1Alpha connects-toJak1 2 connects-toMtor connects-toMhc Class Ii connects-toCaspase 3 connects-toIl 10 connects-toPten connects-toPik3Ca connects-toIfn Gamma connects-toStat1 connects-toE2F1 connects-toP53 connects-toBaff connects-toRb1 connects-toErk1 2 connects-toMdm2 connects-toGalectin 3 connects-toTgf Beta connects-toCgas Sting connects-toSmad4 connects-toFoxo connects-toCdk4 6 connects-toGsk 3B connects-toPerforin connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toLmp1 connects-toIl 4 connects-toTnf Alpha connects-toIl 2 connects-toCtla 4 connects-toHemoglobin connects-toXanthine Oxidase connects-toProton connects-toNitric Oxide connects-toProstaglandins connects-toIron connects-toIl 13 connects-toHepcidin connects-toLeptin connects-toType I Interferon connects-toAdiponectin connects-toResistin connects-toNatural Killer Cell connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toTslp connects-toT Helper Cell connects-toIl 31 connects-toPeriostin connects-toComplement C3 connects-toComplement C5 connects-toC5Ar1 connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toErythropoietin connects-toFactor H connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPhosphorus connects-toZinc connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin

Sources