Atlas One · Host Biology · Scale 07 — System

Primary CNS Lymphoma

PCNSL is ABC-DLBCL confined to CNS; MYD88 L265P ~90%, CD79B ~70%; high-dose methotrexate is the treatment backbone; ibrutinib shows ~50-60% ORR in R/R disease; 5-year OS ~30-40% with HDMTX-based therapy; vitreous IL-10 >10 pg/mL is pathognomonic.

Also known as: PCNSL, primary CNS lymphoma, primary central nervous system lymphoma, CNS lymphoma, cerebral lymphoma, vitreoretinal lymphoma, primary intraocular lymphoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
pcnsl

Primary CNS Lymphoma

PCNSL is ABC-DLBCL confined to CNS; MYD88 L265P ~90%, CD79B ~70%; high-dose methotrexate is the treatment backbone; ibrutinib shows ~50-60% ORR in R/R disease; 5-year OS ~30-40% with HDMTX-based therapy; vitreous IL-10 >10 pg/mL is pathognomonic.

Entry Metadata

FieldValue
IDpcnsl
NamePrimary CNS Lymphoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMyd88 connects-toPd 1 connects-toBtk connects-toIl 6 connects-toBrain connects-toB Cell connects-toEpstein Barr Virus connects-toPtcl connects-toDlbcl connects-toEye

Sources