Atlas One · Host Biology · Scale 07 — System

Multiple Sclerosis

Autoimmune demyelinating CNS disease mediated by autoreactive Th1/Th17 and CD8+ T cells attacking myelin; relapsing-remitting in 85% at onset. Natalizumab, ocrelizumab, and cladribine are high-efficacy DMTs; early aggressive therapy improves long-term disability outcomes.

Also known as: MS, multiple sclerosis, RRMS, PPMS, clinically isolated syndrome, CIS

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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multiple-sclerosis

Multiple Sclerosis

Autoimmune demyelinating CNS disease mediated by autoreactive Th1/Th17 and CD8+ T cells attacking myelin; relapsing-remitting in 85% at onset. Natalizumab, ocrelizumab, and cladribine are high-efficacy DMTs; early aggressive therapy improves long-term disability outcomes.

Entry Metadata

FieldValue
IDmultiple-sclerosis
NameMultiple Sclerosis
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsBrain connects-toOligodendrocyte connects-toT Helper Cell connects-toAstrocyte connects-toIl 17A connects-toCcr5 connects-toEpstein Barr Virus connects-toMyasthenia Gravis connects-toVitamin D connects-toNmo connects-toB Cell connects-toEye connects-toMajor Depressive Disorder connects-toType I Interferon connects-toNeuron connects-toMicroglia connects-toRheumatoid Arthritis connects-toT Cytotoxic Cell connects-toCd20 connects-toNervous System connects-toImmune System connects-toGut Microbiome connects-toRegulatory T Cell connects-toPlasma Cell connects-toMhc Class Ii connects-toMacrophage connects-toIron connects-toSodium connects-toNitric Oxide connects-toGlutamate connects-toSynapse connects-toCalcium connects-toMast Cell connects-toPhoton connects-toPotassium connects-toBone Marrow connects-toElectron connects-toLarge Intestine connects-toKidney connects-toAntibody connects-toReproductive System connects-toSmooth Muscle Cell connects-toMusculoskeletal System connects-toNeutrophil connects-toThyroid connects-toNatural Killer Cell connects-toComplement C3 connects-toPeripheral Nerve connects-toNlrp3 Inflammasome connects-toBdnf connects-toNeuropathic Pain connects-toNf Kb connects-toSepsis connects-toInsomnia Disorder connects-toOsteoporosis connects-toPneumocystis Jirovecii connects-toEpilepsy connects-toCkd connects-toAspergillus Fumigatus connects-toWound Healing connects-toRenal System connects-toDigestive System connects-toVaricella Zoster Virus connects-toRespiratory System connects-toCardiovascular System connects-toIntegumentary System connects-toEndocrine System connects-toLymphatic System connects-toHerpesvirus connects-toCorticosteroids connects-toMigraine connects-toDendritic Cell connects-toTargeted Therapy connects-toAxonal Transport connects-toCancer Chemotherapy connects-toGerminal Center connects-toCidp connects-toInflammatory Bowel Disease connects-toCovid 19 Disease connects-toBipolar Disorder connects-toHippocampus connects-toObsessive Compulsive Disorder connects-toHepatitis B connects-toIntestinal Epithelium connects-toIfn Gamma connects-toTnf Alpha connects-toOsteopontin connects-toBaff connects-toIl 6 connects-toCcl2 connects-toBtk connects-toPerforin connects-toIl 2 connects-toLmp1 connects-toCalcium connects-toIgf 1 connects-toNfe2L2 connects-toCaspase 3 connects-toConnexin43 connects-toIl 23 connects-toJak1 2 connects-toTgf Beta connects-toStat3 connects-toAkt connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toSmad4 connects-toFoxo connects-toErk1 2 connects-toS100A8 A9 connects-toGsk 3B connects-toPik3Ca connects-toHif 1Alpha connects-toAmpk connects-toAutophagy connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toSrc Kinase connects-toIl 1B connects-toArid1A connects-toCalcineurin connects-toEstrogen connects-toLeptin connects-toBcl 2 connects-toIl 4 connects-toIl 10 connects-toProgesterone connects-toXanthine Oxidase connects-toCholesterol connects-toProstaglandins connects-toAstrocyte connects-toCalcium connects-toOmega 3 Fatty Acids connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toMicroglia connects-toNeuron connects-toVitamin D connects-toIl 12 connects-toIl 5 connects-toIge connects-toHistamine connects-toSelenium connects-toSystemic Lupus Erythematosus connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toPeriostin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toVegf connects-toFibronectin connects-toNotch connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin