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multiple-sclerosis
Multiple Sclerosis
Autoimmune demyelinating CNS disease mediated by autoreactive Th1/Th17 and CD8+ T cells attacking myelin; relapsing-remitting in 85% at onset. Natalizumab, ocrelizumab, and cladribine are high-efficacy DMTs; early aggressive therapy improves long-term disability outcomes.
Entry Metadata
| Field | Value |
|---|---|
| ID | multiple-sclerosis |
| Name | Multiple Sclerosis |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
targetsBrain
connects-toOligodendrocyte
connects-toT Helper Cell
connects-toAstrocyte
connects-toIl 17A
connects-toCcr5
connects-toEpstein Barr Virus
connects-toMyasthenia Gravis
connects-toVitamin D
connects-toNmo
connects-toB Cell
connects-toEye
connects-toMajor Depressive Disorder
connects-toType I Interferon
connects-toNeuron
connects-toMicroglia
connects-toRheumatoid Arthritis
connects-toT Cytotoxic Cell
connects-toCd20
connects-toNervous System
connects-toImmune System
connects-toGut Microbiome
connects-toRegulatory T Cell
connects-toPlasma Cell
connects-toMhc Class Ii
connects-toMacrophage
connects-toIron
connects-toSodium
connects-toNitric Oxide
connects-toGlutamate
connects-toSynapse
connects-toCalcium
connects-toMast Cell
connects-toPhoton
connects-toPotassium
connects-toBone Marrow
connects-toElectron
connects-toLarge Intestine
connects-toKidney
connects-toAntibody
connects-toReproductive System
connects-toSmooth Muscle Cell
connects-toMusculoskeletal System
connects-toNeutrophil
connects-toThyroid
connects-toNatural Killer Cell
connects-toComplement C3
connects-toPeripheral Nerve
connects-toNlrp3 Inflammasome
connects-toBdnf
connects-toNeuropathic Pain
connects-toNf Kb
connects-toSepsis
connects-toInsomnia Disorder
connects-toOsteoporosis
connects-toPneumocystis Jirovecii
connects-toEpilepsy
connects-toCkd
connects-toAspergillus Fumigatus
connects-toWound Healing
connects-toRenal System
connects-toDigestive System
connects-toVaricella Zoster Virus
connects-toRespiratory System
connects-toCardiovascular System
connects-toIntegumentary System
connects-toEndocrine System
connects-toLymphatic System
connects-toHerpesvirus
connects-toCorticosteroids
connects-toMigraine
connects-toDendritic Cell
connects-toTargeted Therapy
connects-toAxonal Transport
connects-toCancer Chemotherapy
connects-toGerminal Center
connects-toCidp
connects-toInflammatory Bowel Disease
connects-toCovid 19 Disease
connects-toBipolar Disorder
connects-toHippocampus
connects-toObsessive Compulsive Disorder
connects-toHepatitis B
connects-toIntestinal Epithelium
connects-toIfn Gamma
connects-toTnf Alpha
connects-toOsteopontin
connects-toBaff
connects-toIl 6
connects-toCcl2
connects-toBtk
connects-toPerforin
connects-toIl 2
connects-toLmp1
connects-toCalcium
connects-toIgf 1
connects-toNfe2L2
connects-toCaspase 3
connects-toConnexin43
connects-toIl 23
connects-toJak1 2
connects-toTgf Beta
connects-toStat3
connects-toAkt
connects-toGalectin 3
connects-toStat1
connects-toCgas Sting
connects-toSmad4
connects-toFoxo
connects-toErk1 2
connects-toS100A8 A9
connects-toGsk 3B
connects-toPik3Ca
connects-toHif 1Alpha
connects-toAmpk
connects-toAutophagy
connects-toDnmt3A
connects-toCxcl12
connects-toIl 33
connects-toSrc Kinase
connects-toIl 1B
connects-toArid1A
connects-toCalcineurin
connects-toEstrogen
connects-toLeptin
connects-toBcl 2
connects-toIl 4
connects-toIl 10
connects-toProgesterone
connects-toXanthine Oxidase
connects-toCholesterol
connects-toProstaglandins
connects-toAstrocyte
connects-toCalcium
connects-toOmega 3 Fatty Acids
connects-toIl 13
connects-toAdiponectin
connects-toResistin
connects-toMicroglia
connects-toNeuron
connects-toVitamin D
connects-toIl 12
connects-toIl 5
connects-toIge
connects-toHistamine
connects-toSelenium
connects-toSystemic Lupus Erythematosus
connects-toComplement C5
connects-toC5Ar1
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toTransferrin
connects-toPeriostin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toMelatonin
connects-toTestosterone
connects-toProlactin
connects-toSerotonin
connects-toOxytocin
connects-toVasopressin
connects-toIodine
connects-toMagnesium
connects-toCopper
connects-toZinc
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toCarbon
connects-toHydrogen
connects-toNitrogen
connects-toOxygen
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toVegf
connects-toFibronectin
connects-toNotch
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
Sources
- Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502-1517. · PubMed 18970977
- Polman CH, O'Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006;354(9):899-910. · PubMed 16510744
- Montalban X, Hauser SL, Kappos L, et al. Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis. N Engl J Med. 2017;376(3):209-220. · PubMed 28002688