Atlas One · Host Biology · Scale 04 — Cellular

Smooth Muscle Cell

Involuntary, non-striated, mononucleated cells lining blood vessels, airways, GI tract, bladder, and uterus. Contraction via Ca²⁺-calmodulin-MLCK axis and Rho kinase; relaxation by NO/cGMP/PKG. Phenotype switching from contractile to synthetic drives atherosclerosis and PAH.

Also known as: SMC, vascular smooth muscle cell, VSMC, visceral smooth muscle, myometrium cell

Scale 04 — CellularScale
draftStatus
2026-06-05Last Reviewed
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smooth-muscle-cell

Smooth Muscle Cell

Involuntary, non-striated, mononucleated cells lining blood vessels, airways, GI tract, bladder, and uterus. Contraction via Ca²⁺-calmodulin-MLCK axis and Rho kinase; relaxation by NO/cGMP/PKG. Phenotype switching from contractile to synthetic drives atherosclerosis and PAH.

Entry Metadata

FieldValue
IDsmooth-muscle-cell
NameSmooth Muscle Cell
Statusdraft
Last reviewed2026-06-05
Atlas01-human
Scale04-cellular

Cross-Atlas Connections

part-ofCardiovascular System modulatesNitric Oxide modulated-byCalcium Channel Blockers modulatesRespiratory System connects-toEndothelial Cell connects-toPdgf connects-toAtherosclerosis

Sources