Atlas One · Host Biology · Scale 07 — System

Atherosclerosis

Chronic arterial intimal disease driven by LDL oxidation, macrophage foam cell formation, and smooth muscle migration; vulnerable plaque rupture causes MI and stroke. Statins, PCSK9 inhibitors, and anti-inflammatory therapies (colchicine) are evidence-based interventions.

Also known as: arteriosclerosis, coronary artery disease, CAD, ASCVD, atherosclerotic cardiovascular disease

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
atherosclerosis

Atherosclerosis

Chronic arterial intimal disease driven by LDL oxidation, macrophage foam cell formation, and smooth muscle migration; vulnerable plaque rupture causes MI and stroke. Statins, PCSK9 inhibitors, and anti-inflammatory therapies (colchicine) are evidence-based interventions.

Entry Metadata

FieldValue
IDatherosclerosis
NameAtherosclerosis
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsCardiovascular System connects-toCholesterol connects-toNitric Oxide connects-toMacrophage connects-toPcsk9 connects-toCcl2 connects-toFamilial Hypercholesterolemia connects-toFibronectin treated-byAspirin connects-toCarbon connects-toEndothelial Cell connects-toHeart connects-toStroke connects-toType 2 Diabetes connects-toHypertension connects-toSmooth Muscle Cell connects-toPlatelet connects-toIl 6 connects-toObesity connects-toCalcium connects-toT Helper Cell connects-toCkd connects-toApoe connects-toGut Microbiome connects-toNeutrophil connects-toCollagen connects-toT Cytotoxic Cell connects-toErythrocyte connects-toOxygen connects-toThrombin connects-toKidney connects-toFibrosis connects-toBrain connects-toVegf connects-toPhoton connects-toBone Marrow connects-toLiver connects-toElectron connects-toCopper connects-toLarge Intestine connects-toNeuron connects-toReproductive System connects-toMusculoskeletal System connects-toAntibody connects-toAdipocyte connects-toDietary Fiber connects-toFibrinogen connects-toRegulatory T Cell connects-toRheumatoid Arthritis connects-toNlrp3 Inflammasome connects-toPsoriasis connects-toSystemic Lupus Erythematosus connects-toNf Kb connects-toStat3 connects-toVenous Thromboembolism connects-toHeart Failure connects-toWound Healing connects-toMajor Depressive Disorder connects-toAlzheimers Disease connects-toWound Healing connects-toParkinsons Disease connects-toDigestive System connects-toRenal System connects-toIntegumentary System connects-toImmune System connects-toNervous System connects-toEndocrine System connects-toStatins connects-toLymphatic System connects-toRespiratory System connects-toAce Inhibitors connects-toHerpesvirus connects-toOmega 3 Fatty Acids connects-toTargeted Therapy connects-toArterial Wall connects-toMyocardium connects-toGout connects-toGlomerulus connects-toCardiac Conduction System connects-toHiv Aids connects-toInflammatory Bowel Disease connects-toCovid 19 Disease connects-toNash connects-toType 1 Diabetes connects-toEndothelin 1 connects-toIl 1B connects-toTnf Alpha connects-toHif 1Alpha connects-toTlr4 connects-toS100A8 A9 connects-toIfn Gamma connects-toRage connects-toCaspase 3 connects-toVon Willebrand Factor connects-toCalcium connects-toXanthine Oxidase connects-toGalectin 3 connects-toPdgf connects-toTgf Beta connects-toAngiopoietin connects-toMyd88 connects-toNfe2L2 connects-toAkt connects-toErk1 2 connects-toMtor connects-toJak1 2 connects-toCgas Sting connects-toSmad4 connects-toStat1 connects-toFoxo connects-toPerforin connects-toCdk4 6 connects-toGsk 3B connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toArid1A connects-toMhc Class Ii connects-toTroponin Complex connects-toLeptin connects-toIl 10 connects-toEstrogen connects-toMast Cell connects-toProstaglandins connects-toAdiponectin connects-toInsulin connects-toIl 4 connects-toResistin connects-toHepcidin connects-toIron connects-toIl 13 connects-toZinc connects-toHeart connects-toFamilial Hypercholesterolemia connects-toPlatelet connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toDendritic Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toOsteopontin connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toMagnesium connects-toChloride connects-toSulfur connects-toNitrogen connects-toHydrogen connects-toPhosphorus connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr