Atlas One · Host Biology · Scale 03 — Molecular

Activin A

Activin A (INHBA homodimer, chr7p15.2) is a TGF-β superfamily member; ActRIIB/ALK4 → SMAD2/3 suppresses erythropoiesis and promotes PAH vascular remodeling; luspatercept (ActRIIB-Fc) treats MDS/beta-thalassemia; sotatercept reverses PAH (STELLAR trial 2024).

Also known as: activin A, activin-A, INHBA, inhibin beta A, activin AB, erythroid maturation agent

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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activin-a

Activin A

Activin A (INHBA homodimer, chr7p15.2) is a TGF-β superfamily member; ActRIIB/ALK4 → SMAD2/3 suppresses erythropoiesis and promotes PAH vascular remodeling; luspatercept (ActRIIB-Fc) treats MDS/beta-thalassemia; sotatercept reverses PAH (STELLAR trial 2024).

Entry Metadata

FieldValue
IDactivin-a
NameActivin A
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMds connects-toMyostatin connects-toCardiovascular System connects-toPulmonary Arterial Hypertension connects-toThalassemia connects-toFibroblast

Sources