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thalassemia
Thalassemia
Thalassaemias are haemoglobinopathies from α- or β-globin chain imbalance; β-thalassaemia major requires lifelong transfusion; ineffective erythropoiesis → iron overload despite anaemia; betibeglogene autotemcel (Zynteglo) and CRISPR-based Casgevy are approved gene therapies.
Entry Metadata
| Field | Value |
|---|---|
| ID | thalassemia |
| Name | Thalassemia |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toHemoglobin
connects-toTransferrin
connects-toHepcidin
connects-toSickle Cell Disease
connects-toG6Pd
connects-toActivin A
connects-toErythrocyte
connects-toIron
connects-toHeart
connects-toMalaria
connects-toBone Marrow
connects-toIron Deficiency Anemia
connects-toSpleen
connects-toLiver
connects-toOsteoporosis
connects-toErythropoietin
connects-toOxygen
connects-toEndocrine System
connects-toFerroportin
connects-toHeart Failure
connects-toMusculoskeletal System
connects-toPlacenta
connects-toReproductive System
connects-toMacrophage
connects-toPancreas
connects-toT Cytotoxic Cell
connects-toCalcium
connects-toCardiomyocyte
connects-toThyroid
connects-toGrowth Hormone
connects-toZinc
connects-toOsteoclast
connects-toSkin
connects-toPhoton
connects-toEndothelial Cell
connects-toFibrosis
connects-toElectron
connects-toKidney
connects-toEye
connects-toAntibody
connects-toNeuron
connects-toPlatelet
connects-toAdrenal Gland
connects-toNeutrophil
connects-toVitamin D
connects-toVenous Thromboembolism
connects-toOsteoblast
connects-toSmall Intestine
connects-toPulmonary Arterial Hypertension
connects-toHepatitis C
connects-toNitric Oxide
connects-toHcc
connects-toNf Kb
connects-toSepsis
connects-toCkd
connects-toGout
connects-toMajor Depressive Disorder
connects-toType 2 Diabetes
connects-toNeisseria Meningitidis
connects-toStroke
connects-toDigestive System
connects-toIntegumentary System
connects-toGeneralized Anxiety Disorder
connects-toCardiovascular System
connects-toLymphatic System
connects-toNervous System
connects-toImmune System
connects-toRenal System
connects-toRespiratory System
connects-toStreptococcus Pneumoniae
connects-toHepatocyte
connects-toMds
connects-toTargeted Therapy
connects-toCancer Chemotherapy
connects-toCortical Bone
connects-toMyocardium
connects-toHepatic Lobule
connects-toBrain
connects-toGvhd
connects-toGerminal Center
connects-toCardiac Conduction System
connects-toIntestinal Epithelium
connects-toAplastic Anemia
connects-toWound Healing
connects-toHif 1Alpha
connects-toEndothelin 1
connects-toTnf Alpha
connects-toTlr4
connects-toRankl
connects-toBnp
connects-toCaspase 3
connects-toVegf
connects-toVon Willebrand Factor
connects-toBcl 2
connects-toXanthine Oxidase
connects-toRage
connects-toSmad4
connects-toNfe2L2
connects-toIl 6
connects-toTgf Beta
connects-toMyd88
connects-toThrombin
connects-toJak1 2
connects-toAkt
connects-toErk1 2
connects-toGalectin 3
connects-toStat3
connects-toCgas Sting
connects-toFoxo
connects-toStat1
connects-toS100A8 A9
connects-toGsk 3B
connects-toPik3Ca
connects-toAmpk
connects-toAutophagy
connects-toSrc Kinase
connects-toDnmt3A
connects-toCcr5
connects-toCxcl12
connects-toKit
connects-toRunx1
connects-toNotch
connects-toArid1A
connects-toInsulin
connects-toTestosterone
connects-toMhc Class Ii
connects-toThyroid Hormones
connects-toEstrogen
connects-toPth
connects-toProtein C
connects-toIl 1B
connects-toCholesterol
connects-toCortical Bone
connects-toIl 4
connects-toZinc
connects-toIl 13
connects-toLeptin
connects-toAdiponectin
connects-toErythrocyte
connects-toSpleen
connects-toMalaria
connects-toResistin
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 17A
connects-toIl 23
connects-toComplement C3
connects-toT Helper Cell
connects-toIge
connects-toComplement C5
connects-toC5Ar1
connects-toFactor H
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toMelatonin
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toMagnesium
connects-toCopper
connects-toPotassium
connects-toPhosphorus
connects-toCarbon
connects-toChloride
connects-toHydrogen
connects-toNitrogen
connects-toSulfur
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toIl 2
connects-toFibronectin
connects-toIgf 1
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
Sources
- Weatherall DJ. The inherited diseases of hemoglobin are an emerging global health burden. Blood. 2010;115(22):4331-4336. · PubMed 20233970
- Cappellini MD, Cohen A, Porter J, et al. (eds). Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT). 3rd ed. Thalassaemia International Federation; 2014.
- Thompson AA, Walters MC, Kwiatkowski J, et al. Gene therapy in patients with transfusion-dependent β-thalassemia. N Engl J Med. 2018;378(16):1479-1493. · PubMed 29669226