Atlas One · Host Biology · Scale 07 — System

Thalassemia

Thalassaemias are haemoglobinopathies from α- or β-globin chain imbalance; β-thalassaemia major requires lifelong transfusion; ineffective erythropoiesis → iron overload despite anaemia; betibeglogene autotemcel (Zynteglo) and CRISPR-based Casgevy are approved gene therapies.

Also known as: thalassaemia, thalassemia, beta-thalassemia, alpha-thalassemia, β-thalassaemia major, Cooley's anaemia, thal major, HbH disease, hydrops fetalis, thal trait

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
thalassemia

Thalassemia

Thalassaemias are haemoglobinopathies from α- or β-globin chain imbalance; β-thalassaemia major requires lifelong transfusion; ineffective erythropoiesis → iron overload despite anaemia; betibeglogene autotemcel (Zynteglo) and CRISPR-based Casgevy are approved gene therapies.

Entry Metadata

FieldValue
IDthalassemia
NameThalassemia
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toHemoglobin connects-toTransferrin connects-toHepcidin connects-toSickle Cell Disease connects-toG6Pd connects-toActivin A connects-toErythrocyte connects-toIron connects-toHeart connects-toMalaria connects-toBone Marrow connects-toIron Deficiency Anemia connects-toSpleen connects-toLiver connects-toOsteoporosis connects-toErythropoietin connects-toOxygen connects-toEndocrine System connects-toFerroportin connects-toHeart Failure connects-toMusculoskeletal System connects-toPlacenta connects-toReproductive System connects-toMacrophage connects-toPancreas connects-toT Cytotoxic Cell connects-toCalcium connects-toCardiomyocyte connects-toThyroid connects-toGrowth Hormone connects-toZinc connects-toOsteoclast connects-toSkin connects-toPhoton connects-toEndothelial Cell connects-toFibrosis connects-toElectron connects-toKidney connects-toEye connects-toAntibody connects-toNeuron connects-toPlatelet connects-toAdrenal Gland connects-toNeutrophil connects-toVitamin D connects-toVenous Thromboembolism connects-toOsteoblast connects-toSmall Intestine connects-toPulmonary Arterial Hypertension connects-toHepatitis C connects-toNitric Oxide connects-toHcc connects-toNf Kb connects-toSepsis connects-toCkd connects-toGout connects-toMajor Depressive Disorder connects-toType 2 Diabetes connects-toNeisseria Meningitidis connects-toStroke connects-toDigestive System connects-toIntegumentary System connects-toGeneralized Anxiety Disorder connects-toCardiovascular System connects-toLymphatic System connects-toNervous System connects-toImmune System connects-toRenal System connects-toRespiratory System connects-toStreptococcus Pneumoniae connects-toHepatocyte connects-toMds connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toCortical Bone connects-toMyocardium connects-toHepatic Lobule connects-toBrain connects-toGvhd connects-toGerminal Center connects-toCardiac Conduction System connects-toIntestinal Epithelium connects-toAplastic Anemia connects-toWound Healing connects-toHif 1Alpha connects-toEndothelin 1 connects-toTnf Alpha connects-toTlr4 connects-toRankl connects-toBnp connects-toCaspase 3 connects-toVegf connects-toVon Willebrand Factor connects-toBcl 2 connects-toXanthine Oxidase connects-toRage connects-toSmad4 connects-toNfe2L2 connects-toIl 6 connects-toTgf Beta connects-toMyd88 connects-toThrombin connects-toJak1 2 connects-toAkt connects-toErk1 2 connects-toGalectin 3 connects-toStat3 connects-toCgas Sting connects-toFoxo connects-toStat1 connects-toS100A8 A9 connects-toGsk 3B connects-toPik3Ca connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toDnmt3A connects-toCcr5 connects-toCxcl12 connects-toKit connects-toRunx1 connects-toNotch connects-toArid1A connects-toInsulin connects-toTestosterone connects-toMhc Class Ii connects-toThyroid Hormones connects-toEstrogen connects-toPth connects-toProtein C connects-toIl 1B connects-toCholesterol connects-toCortical Bone connects-toIl 4 connects-toZinc connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toErythrocyte connects-toSpleen connects-toMalaria connects-toResistin connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 17A connects-toIl 23 connects-toComplement C3 connects-toT Helper Cell connects-toIge connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toIl 2 connects-toFibronectin connects-toIgf 1 connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine