Atlas One · Host Biology · Scale 07 — System

Aplastic Anemia

Aplastic anemia (AA) is a bone marrow failure syndrome; autoreactive CD8+ T cells destroy HSCs via perforin/granzyme → pancytopenia. SAA: ANC <500/µL, plt <20,000/µL, reticulocytes <20,000/µL. Treatment: HSCT (young, matched donor) or ATG + cyclosporine + eltrombopag.

Also known as: AA, aplastic anaemia, severe aplastic anemia, SAA, very severe aplastic anemia, VSAA, bone marrow failure

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
aplastic-anemia

Aplastic Anemia

Aplastic anemia (AA) is a bone marrow failure syndrome; autoreactive CD8+ T cells destroy HSCs via perforin/granzyme → pancytopenia. SAA: ANC <500/µL, plt <20,000/µL, reticulocytes <20,000/µL. Treatment: HSCT (young, matched donor) or ATG + cyclosporine + eltrombopag.

Entry Metadata

FieldValue
IDaplastic-anemia
NameAplastic Anemia
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsBone Marrow connects-toPnh connects-toPerforin connects-toThrombopoietin connects-toT Cytotoxic Cell connects-toIfn Gamma connects-toMds connects-toAll connects-toNeutrophil connects-toPlatelet connects-toErythrocyte connects-toHepatitis C connects-toImmune System connects-toAml connects-toGvhd connects-toRegulatory T Cell connects-toT Helper Cell connects-toErythropoietin connects-toSystemic Lupus Erythematosus connects-toThymus connects-toCytokine Storm connects-toImmunoglobulin G connects-toTert connects-toPhoton connects-toLiver connects-toIron connects-toCalcineurin connects-toSpleen connects-toTnf Alpha connects-toNatural Killer Cell connects-toOxygen connects-toHeart connects-toDendritic Cell connects-toCarbon connects-toSkin connects-toOsteoblast connects-toCxcl12 connects-toElectron connects-toLarge Intestine connects-toLung connects-toAntibody connects-toReproductive System connects-toBrain connects-toHepatitis B connects-toMusculoskeletal System connects-toKidney connects-toMacrophage connects-toLeishmaniasis connects-toMyelofibrosis connects-toEpstein Barr Virus connects-toSepsis connects-toIl 2 connects-toStat3 connects-toNf Kb connects-toVenous Thromboembolism connects-toAspergillus Fumigatus connects-toCandida Albicans connects-toHeart Failure connects-toCkd connects-toVaricella Zoster Virus connects-toMajor Depressive Disorder connects-toIntegumentary System connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toRespiratory System connects-toDigestive System connects-toCardiovascular System connects-toLymphatic System connects-toRenal System connects-toCancer Chemotherapy connects-toIbuprofen connects-toHiv 1 connects-toTargeted Therapy connects-toThalassemia connects-toHepatic Lobule connects-toIron Deficiency Anemia connects-toIntestinal Epithelium connects-toSickle Cell Disease connects-toHiv connects-toEpilepsy connects-toCortical Bone connects-toDengue Virus connects-toTestosterone connects-toPlacenta connects-toIl 17A connects-toIl 6 connects-toFlt3 connects-toKit connects-toCaspase 3 connects-toNlrp3 Inflammasome connects-toMpl connects-toStat1 connects-toTgf Beta connects-toMhc Class Ii connects-toGlucocorticoid Receptor connects-toDnmt3A connects-toBcl 2 connects-toAkt connects-toIl 10 connects-toJak1 2 connects-toIl 12 connects-toRunx1 connects-toMtor connects-toErk1 2 connects-toCgas Sting connects-toGalectin 3 connects-toSmad4 connects-toFoxo connects-toHif 1Alpha connects-toS100A8 A9 connects-toGsk 3B connects-toPik3Ca connects-toSrc Kinase connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toMdm2 connects-toIl 1B connects-toIl 33 connects-toComplement C3 connects-toArid1A connects-toAdenosine connects-toOsteopontin connects-toHemoglobin connects-toHepcidin connects-toCtla 4 connects-toIl 4 connects-toXanthine Oxidase connects-toTroponin Complex connects-toIl 13 connects-toVegf connects-toProstaglandins connects-toCopper connects-toZinc connects-toLeptin connects-toType I Interferon connects-toAdiponectin connects-toResistin connects-toMds connects-toT Helper Cell connects-toIron connects-toIl 5 connects-toIl 23 connects-toIge connects-toB Cell connects-toPlasma Cell connects-toMast Cell connects-toC5Ar1 connects-toComplement C5 connects-toTransferrin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toTslp connects-toBradykinin connects-toHistamine connects-toMelatonin connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toPotassium connects-toCalcium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine