Atlas One · Host Biology · Scale 07 — System

Aplastic Anemia

Aplastic anemia (AA) is a bone marrow failure syndrome; autoreactive CD8+ T cells destroy HSCs via perforin/granzyme → pancytopenia. SAA: ANC <500/µL, plt <20,000/µL, reticulocytes <20,000/µL. Treatment: HSCT (young, matched donor) or ATG + cyclosporine + eltrombopag.

Also known as: AA, aplastic anaemia, severe aplastic anemia, SAA, very severe aplastic anemia, VSAA, bone marrow failure

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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aplastic-anemia

Aplastic Anemia

Aplastic anemia (AA) is a bone marrow failure syndrome; autoreactive CD8+ T cells destroy HSCs via perforin/granzyme → pancytopenia. SAA: ANC <500/µL, plt <20,000/µL, reticulocytes <20,000/µL. Treatment: HSCT (young, matched donor) or ATG + cyclosporine + eltrombopag.

Entry Metadata

FieldValue
IDaplastic-anemia
NameAplastic Anemia
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

targetsBone Marrow connects-toPnh connects-toPerforin connects-toThrombopoietin

Sources