Atlas One · Host Biology · Scale 03 — Molecular

CTLA-4

CD152; inhibitory receptor on T cells competing with CD28 for B7-1/B7-2 co-stimulation — suppresses T cell priming in lymph nodes. Blocked by ipilimumab (anti-CTLA-4 IgG1); combined with anti-PD-1 (nivolumab) as standard of care in advanced melanoma and RCC.

Also known as: CD152, cytotoxic T-lymphocyte-associated protein 4, CTLA4, CD152 checkpoint

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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ctla-4

CTLA-4

CD152; inhibitory receptor on T cells competing with CD28 for B7-1/B7-2 co-stimulation — suppresses T cell priming in lymph nodes. Blocked by ipilimumab (anti-CTLA-4 IgG1); combined with anti-PD-1 (nivolumab) as standard of care in advanced melanoma and RCC.

Entry Metadata

FieldValue
IDctla-4
NameCTLA-4
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

modulated-byT Helper Cell modulated-byT Cytotoxic Cell modulated-byRegulatory T Cell connects-toPd 1 connects-toMelanoma connects-toDendritic Cell target-ofCheckpoint Inhibitors

Sources