Atlas One · Host Biology · Scale 03 — Molecular

SMAD4

SMAD4 is the common-mediator SMAD that bridges TGF-β/BMP-activated R-SMADs (SMAD2/3, SMAD1/5/8) to nuclear transcriptional complexes; LOF → TGF-β cytostatic program lost → tumor progression; germline SMAD4 = juvenile polyposis syndrome; somatic loss in ~55% PDAC and ~15% CRC.

Also known as: SMAD4, DPC4, deleted in pancreatic cancer 4, SMAD4 tumor suppressor, SMAD4 co-SMAD, SMAD4 JPS, SMAD4 PDAC, SMAD4 CRC, 18q loss, common mediator SMAD

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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smad4

SMAD4

SMAD4 is the common-mediator SMAD that bridges TGF-β/BMP-activated R-SMADs (SMAD2/3, SMAD1/5/8) to nuclear transcriptional complexes; LOF → TGF-β cytostatic program lost → tumor progression; germline SMAD4 = juvenile polyposis syndrome; somatic loss in ~55% PDAC and ~15% CRC.

Entry Metadata

FieldValue
IDsmad4
NameSMAD4
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toTgf Beta connects-toColorectal Cancer connects-toPancreatic Cancer connects-toJuvenile Polyposis Syndrome

Sources