Atlas One · Host Biology · Scale 07 — System

Juvenile Polyposis Syndrome

Juvenile polyposis syndrome (JPS) is caused by germline SMAD4 (~20%) or BMPR1A (~25%) mutations; hamartomatous GI polyps with CRC risk ~40-50% by age 60; SMAD4-JPS patients also have hereditary hemorrhagic telangiectasia features; colonoscopy from age 15.

Also known as: juvenile polyposis syndrome, JPS, SMAD4 JPS, BMPR1A JPS, hamartomatous polyposis, juvenile polyps GI, JPS CRC risk, JPS HHT overlap, hereditary juvenile polyposis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
juvenile-polyposis-syndrome

Juvenile Polyposis Syndrome

Juvenile polyposis syndrome (JPS) is caused by germline SMAD4 (~20%) or BMPR1A (~25%) mutations; hamartomatous GI polyps with CRC risk ~40-50% by age 60; SMAD4-JPS patients also have hereditary hemorrhagic telangiectasia features; colonoscopy from age 15.

Entry Metadata

FieldValue
IDjuvenile-polyposis-syndrome
NameJuvenile Polyposis Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSmad4 connects-toTgf Beta connects-toColorectal Cancer connects-toApc connects-toPten connects-toPeutz Jeghers Syndrome connects-toLarge Intestine connects-toLynch Syndrome connects-toFap connects-toStomach connects-toGastric Cancer connects-toMutyh Associated Polyposis connects-toIntestinal Epithelium

Sources