Atlas One · Host Biology · Scale 07 — System

Juvenile Polyposis Syndrome

Juvenile polyposis syndrome (JPS) is caused by germline SMAD4 (~20%) or BMPR1A (~25%) mutations; hamartomatous GI polyps with CRC risk ~40-50% by age 60; SMAD4-JPS patients also have hereditary hemorrhagic telangiectasia features; colonoscopy from age 15.

Also known as: juvenile polyposis syndrome, JPS, SMAD4 JPS, BMPR1A JPS, hamartomatous polyposis, juvenile polyps GI, JPS CRC risk, JPS HHT overlap, hereditary juvenile polyposis

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
juvenile-polyposis-syndrome

Juvenile Polyposis Syndrome

Juvenile polyposis syndrome (JPS) is caused by germline SMAD4 (~20%) or BMPR1A (~25%) mutations; hamartomatous GI polyps with CRC risk ~40-50% by age 60; SMAD4-JPS patients also have hereditary hemorrhagic telangiectasia features; colonoscopy from age 15.

Entry Metadata

FieldValue
IDjuvenile-polyposis-syndrome
NameJuvenile Polyposis Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSmad4 connects-toTgf Beta connects-toColorectal Cancer connects-toApc connects-toPten connects-toPeutz Jeghers Syndrome connects-toLarge Intestine connects-toLynch Syndrome connects-toFap connects-toStomach connects-toGastric Cancer connects-toMutyh Associated Polyposis connects-toIntestinal Epithelium connects-toPulmonary Arterial Hypertension connects-toCowden Syndrome connects-toPancreatic Cancer connects-toWnt Beta Catenin connects-toSmall Intestine connects-toIron Deficiency Anemia connects-toDigestive System connects-toCardiovascular System connects-toHereditary Diffuse Gastric Cancer connects-toFibroblast connects-toStk11 connects-toCollagen connects-toEndothelial Cell connects-toVegf connects-toMacrophage connects-toIron connects-toLung connects-toDendritic Cell connects-toOxygen connects-toBrain connects-toFibrosis connects-toPhoton connects-toLiver connects-toBone Marrow connects-toElectron connects-toSkin connects-toEye connects-toErythrocyte connects-toAntibody connects-toPancreas connects-toStroke connects-toActivin A connects-toHeart connects-toMtor connects-toMast Cell connects-toEsophageal Cancer connects-toP53 connects-toVenous Thromboembolism connects-toSepsis connects-toStat3 connects-toNf Kb connects-toAnemia Of Chronic Disease connects-toHeart Failure connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toWound Healing connects-toNeuropathic Pain connects-toGeneralized Anxiety Disorder connects-toIntegumentary System connects-toRespiratory System connects-toNervous System connects-toLymphatic System connects-toRenal System connects-toImmune System connects-toReproductive System connects-toEndocrine System connects-toDietary Fiber connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toStaphylococcus Aureus connects-toMarfan Syndrome connects-toArterial Wall connects-toEndocardium connects-toAlveolus connects-toHepatic Lobule connects-toLi Fraumeni Syndrome connects-toTuberous Sclerosis Complex connects-toAngiopoietin connects-toMyocardium connects-toProstaglandins connects-toIl 6 connects-toSmooth Muscle Cell connects-toAkt connects-toMyc connects-toHif 1Alpha connects-toKras connects-toTert connects-toCcl2 connects-toNitric Oxide connects-toEgfr connects-toCaspase 3 connects-toEndothelin 1 connects-toMlh1 connects-toMutyh connects-toErk1 2 connects-toPik3Ca connects-toCdh1 connects-toJak1 2 connects-toMyd88 connects-toRb1 connects-toGalectin 3 connects-toCdkn2A connects-toCgas Sting connects-toStat1 connects-toCdk4 6 connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toPerforin connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toHemoglobin connects-toMhc Class Ii connects-toIl 2 connects-toT Cytotoxic Cell connects-toXanthine Oxidase connects-toIl 10 connects-toIl 4 connects-toCholesterol connects-toLeptin connects-toIl 13 connects-toHepcidin connects-toAdiponectin connects-toResistin connects-toZinc connects-toCalcium connects-toIl 5 connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toPlasma Cell connects-toNatural Killer Cell connects-toB Cell connects-toC5Ar1 connects-toTransferrin connects-toTslp connects-toPeriostin connects-toVitamin D connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toCarbon connects-toChloride connects-toNitrogen connects-toHydrogen connects-toPhosphorus connects-toPotassium connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr

Sources